Krcméry V, Antal M, Havlík J, Knothe H
J Hyg Epidemiol Microbiol Immunol. 1985;29(4):409-15.
Transfer of Cefamandole resistance was demonstrated from strains of Citrobacter freundii as well as from individual strains of Enterobacter cloacae, Acinetobacter anitratus and Klebsiella pneumoniae isolated from patients in two newborn units. In Citrobacter freundii, Cefamandole resistance was transferred always with Cephalotin resistance as well as with a TEM-like beta lactamase (conferring resistance to Ampicillin, Carbenicillin and Azlocillin). Citrobacter freundii strains from Hospital I were completely susceptible to gentamicin, while strains of other species, resistant to Cefamandole plus Cephalotin, were resistant to Gentamicin as well, and transferred this resistance, too. In one Enterobacter cloacae strain from Hospital I, Cefamandole resistance could be separated from resistance to Cephalotin, but only in clones selected with gentamicin and not with any of the cephalosporins. Acinetobacter anitratus strain was also resistant to Cefotaxime, but did not transfer this resistance. It might be concluded that special nosocomial bacteria may carry plasmids conferring a transferable type of resistance to Cefamandole together with resistance to classical cephalosporines. Second cycle of transfers, i.e. between two variants of E. coli K-12 strains confirmed the contransferability of Cefamandole and Cephalotin resistance.
在两个新生儿病房中，从弗氏柠檬酸杆菌菌株以及从阴沟肠杆菌、鲍曼不动杆菌和肺炎克雷伯菌的个别菌株中证实了头孢孟多耐药性的转移。在弗氏柠檬酸杆菌中，头孢孟多耐药性总是与头孢噻吩耐药性以及一种类似TEM的β-内酰胺酶（赋予对氨苄西林、羧苄西林和阿洛西林的耐药性）一起转移。医院I的弗氏柠檬酸杆菌菌株对庆大霉素完全敏感，而其他对头孢孟多加头孢噻吩耐药的菌株也对庆大霉素耐药，并转移了这种耐药性。在医院I的一株阴沟肠杆菌中，头孢孟多耐药性可以与头孢噻吩耐药性分离，但仅在用庆大霉素而非任何头孢菌素选择的克隆中。鲍曼不动杆菌菌株也对头孢噻肟耐药，但不转移这种耐药性。可以得出结论，特殊的医院细菌可能携带质粒，赋予对头孢孟多的可转移耐药类型以及对经典头孢菌素的耐药性。第二轮转移，即在大肠杆菌K-12菌株的两个变体之间进行的转移，证实了头孢孟多和头孢噻吩耐药性的共同转移性。
