Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Twelve Bridges Road, Jinniu District, Chengdu City, 610000, China.
Zigong First People's Hospital, No. 42, Shangyihao Yizhi Road, Ziliujing District, Zigong City, 641000, China.
BMC Womens Health. 2024 Aug 6;24(1):444. doi: 10.1186/s12905-024-03290-x.
The aim of this study is to evaluate the findings of existing systematic reviews (SRs) and provide scientific evidence on the efficacy and safety of whole-body vibration (WBV) in improving bone mineral density (BMD) in postmenopausal women, to provide recommendations and guidance for future high-quality clinical research and SRs.
We conducted searches in six databases (SinoMed, CNKI, Cochrane Library, Embase, PubMed, Web of Science) from the inception of the databases until July 31, 2023. The language was limited to Chinese or English. The methodological quality, risk of bias, and evidence grade of outcomes were evaluated using AMSTAR-2, ROBIS, and GRADE, respectively. Additionally, the degree of overlap in randomized controlled trials (RCTs) among the SRs was calculated using corrected covered area (CCA). Furthermore, we performed quantitative synthesis or descriptive analysis of the relevant data. All relevant operations were independently conducted by two individuals.
A total of 15 SRs were included in the analysis, out of which three were qualitative descriptions and 12 were meta-analyses. According to AMSTAR-2, only two SRs were rated as low or moderate, while the remaining 13 SRs were rated as critically low quality. The ROBIS assessment indicated that seven SRs had a low risk of bias, while 8 SRs had a high risk of bias. The overall findings suggest that WBV does not have a significant advantage in improving BMD in postmenopausal women. Furthermore, the CCA results revealed a high overlap in RCTs across five outcomes among the 15 SRs. Only five SRs reported specific adverse reactions/events experienced by participants after WBV interventions, and none of the SRs reported any severe adverse events.
The existing evidence cannot establish definitive advantages of WBV in improving BMD in postmenopausal women. Therefore, we do not recommend the use of WBV for improving BMD in postmenopausal women. However, WBV may have potential value in maintaining BMD in postmenopausal women, further research is needed to confirm these findings.
本研究旨在评估现有系统评价（SRs）的结果，为绝经后妇女全身振动（WBV）改善骨密度（BMD）的疗效和安全性提供科学证据，为未来高质量的临床研究和 SRs 提供建议和指导。
我们在六个数据库（SinoMed、CNKI、Cochrane Library、Embase、PubMed、Web of Science）中进行了检索，检索时间从数据库建立到 2023 年 7 月 31 日。语言限于中文或英文。使用 AMSTAR-2、ROBIS 和 GRADE 分别评估结局的方法学质量、偏倚风险和证据等级。此外，使用校正涵盖面积（CCA）计算 SR 中随机对照试验（RCT）的重叠程度。还对相关数据进行了定量综合或描述性分析。所有相关操作均由两名独立人员进行。
共纳入 15 项 SR 分析，其中 3 项为定性描述，12 项为荟萃分析。根据 AMSTAR-2，只有 2 项 SR 被评为低或中度，其余 13 项 SR 被评为严重低质量。ROBIS 评估表明，7 项 SR 存在低偏倚风险，而 8 项 SR 存在高偏倚风险。总体研究结果表明，WBV 在改善绝经后妇女 BMD 方面没有显著优势。此外，CCA 结果表明，15 项 SR 中 5 项结局的 RCT 之间存在高度重叠。只有 5 项 SR 报告了参与者接受 WBV 干预后的特定不良反应/事件，没有一项 SR 报告了任何严重不良事件。
现有证据不能确定 WBV 在改善绝经后妇女 BMD 方面的优势。因此，我们不建议使用 WBV 来改善绝经后妇女的 BMD。然而，WBV 可能对维持绝经后妇女的 BMD 具有潜在价值，需要进一步研究来证实这些发现。
