Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Institute for Research in Operative Medicine, Witten/Herdecke University, Witten, Germany.
BMJ. 2022 Aug 9;378:e070849. doi: 10.1136/bmj-2022-070849.
To develop a reporting guideline for overviews of reviews of healthcare interventions.
Development of the preferred reporting items for overviews of reviews (PRIOR) statement.
Core team (seven individuals) led day-to-day operations, and an expert advisory group (three individuals) provided methodological advice. A panel of 100 experts (authors, editors, readers including members of the public or patients) was invited to participate in a modified Delphi exercise. 11 expert panellists (chosen on the basis of expertise, and representing relevant stakeholder groups) were invited to take part in a virtual face-to-face meeting to reach agreement (≥70%) on final checklist items. 21 authors of recently published overviews were invited to pilot test the checklist.
International consensus.
Four stage process established by the EQUATOR Network for developing reporting guidelines in health research: project launch (establish a core team and expert advisory group, register intent), evidence reviews (systematic review of published overviews to describe reporting quality, scoping review of methodological guidance and author reported challenges related to undertaking overviews of reviews), modified Delphi exercise (two online Delphi surveys to reach agreement (≥70%) on relevant reporting items followed by a virtual face-to-face meeting), and development of the reporting guideline.
From the evidence reviews, we drafted an initial list of 47 potentially relevant reporting items. An international group of 52 experts participated in the first Delphi survey (52% participation rate); agreement was reached for inclusion of 43 (91%) items. 44 experts (85% retention rate) completed the second Delphi survey, which included the four items lacking agreement from the first survey and five new items based on respondent comments. During the second round, agreement was not reached for the inclusion or exclusion of the nine remaining items. 19 individuals (6 core team and 3 expert advisory group members, and 10 expert panellists) attended the virtual face-to-face meeting. Among the nine items discussed, high agreement was reached for the inclusion of three and exclusion of six. Six authors participated in pilot testing, resulting in minor wording changes. The final checklist includes 27 main items (with 19 sub-items) across all stages of an overview of reviews.
PRIOR fills an important gap in reporting guidance for overviews of reviews of healthcare interventions. The checklist, along with rationale and example for each item, provides guidance for authors that will facilitate complete and transparent reporting. This will allow readers to assess the methods used in overviews of reviews of healthcare interventions and understand the trustworthiness and applicability of their findings.
为医疗干预措施系统评价概述制定报告规范。
首选报告项目的制定综述（PRIOR）声明。
核心团队（七人）领导日常运作，专家咨询小组（三人）提供方法学建议。邀请了 100 名专家组成员（作者、编辑、读者，包括公众或患者成员）参加一项经过修改的德尔菲专家意见调查。邀请了 11 名专家小组成员（根据专业知识选择，并代表相关利益相关者群体）参加虚拟面对面会议，以就最终清单项目达成（≥70%）一致意见。邀请了 21 名最近发表的综述作者对清单进行试点测试。
国际共识。
EQUATOR 网络为制定健康研究报告指南而建立的四阶段流程：项目启动（建立核心团队和专家咨询小组，注册意向）、证据审查（对已发表的系统评价进行综述，以描述报告质量，对方法学指导和作者报告的与开展系统评价概述相关的挑战进行范围审查）、修改后的德尔菲专家意见调查（两次在线德尔菲调查，以达成（≥70%）对相关报告项目的一致意见，然后举行虚拟面对面会议）和报告指南的制定。
从证据审查中，我们起草了一份初步的 47 项潜在相关报告项目清单。来自国际的 52 名专家参加了第一次德尔菲调查（参与率为 52%）；达成了纳入 43 项（91%）项目的一致意见。44 名专家（保留率为 85%）完成了第二次德尔菲调查，其中包括第一轮调查中没有达成一致的四项和基于受访者意见的五项新内容。在第二轮调查中，九项剩余项目的纳入或排除没有达成一致意见。19 人（核心团队 6 人，专家咨询小组 3 人，专家小组成员 10 人）参加了虚拟面对面会议。在讨论的九项内容中，对纳入三项和排除六项达成了高度一致。六名作者参与了试点测试，导致措辞略有变化。最终清单包括综述的所有阶段的 27 项主要项目（包括 19 项子项目）。
PRIOR 填补了医疗干预措施系统评价报告指南的一个重要空白。清单以及每个项目的基本原理和示例，为作者提供了指导，这将促进全面和透明的报告。这将使读者能够评估医疗干预措施系统评价概述中使用的方法，并了解其研究结果的可信度和适用性。
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