Yodfat Y, Fidel J, Bloom D S
J Hypertens Suppl. 1985 Nov;3(2):S155-8.
A controlled study was conducted in hypertensive patients to investigate whether captopril can be substituted for the various other antihypertensive drugs (not including diuretics) to reduce side effects and improve the quality of life. Captopril in a twice daily dose of 25-50 mg, was substituted and titrated in 54 patients. Fifty-two patients, matched by age and sex, comprised the control group, and were treated with a variety of agents. During a follow-up of 9 months, 44 of the patients receiving captopril (81%) achieved the goal of supine blood pressure less than 90 mmHg. Captopril was discontinued in two patients due to side effects. Mild proteinuria was observed in two patients. A significant reduction in scores or rates of side effects (numbness, blurred vision, insomnia, vivid dreams, cold extremities, sleepiness, sexual dysfunction and fatigue) and improvement in quality of life (general feeling, mood and concentration) was observed in the study group compared with the control group. Captopril alone in a twice daily dose of 25-50 mg, or in co-treatment with thiazide, provided sustained blood pressure control with minimal side effects and improvement in quality of life compared with the treatment of hypertension with beta-blockers, vasodilators or methyldopa.
在高血压患者中进行了一项对照研究，以调查卡托普利是否可以替代其他各种抗高血压药物（不包括利尿剂）来减少副作用并改善生活质量。对54例患者进行了卡托普利替代治疗，剂量为每日两次，每次25 - 50毫克，并进行滴定。52例年龄和性别匹配的患者组成对照组，接受多种药物治疗。在9个月的随访期间，接受卡托普利治疗的患者中有44例（81%）达到了仰卧位血压低于90 mmHg的目标。两名患者因副作用停用了卡托普利。两名患者出现轻度蛋白尿。与对照组相比，研究组患者的副作用评分或发生率（麻木、视力模糊、失眠、多梦、四肢发冷、嗜睡、性功能障碍和疲劳）显著降低，生活质量（总体感觉、情绪和注意力）得到改善。与使用β受体阻滞剂、血管扩张剂或甲基多巴治疗高血压相比，每日两次剂量为25 - 50毫克的卡托普利单独使用或与噻嗪类药物联合治疗可提供持续的血压控制，副作用最小，生活质量得到改善。
