Yensen R
J Psychoactive Drugs. 1985 Oct-Dec;17(4):267-77. doi: 10.1080/02791072.1985.10524331.
A review of the historical trends in LSD research clearly indicates that LSD and similar drugs are too powerful and unique in their psychological effects to be mistaken for and studied as just another group of psychotropic compounds. The importance of the theoretical understanding and expectations of the researchers in determining the subjective effects and results of LSD treatment is undeniable. In addition, double-blind controlled studies have been demonstrated to be an inappropriate methodology for studying LSD, because it is not feasible to create an effective blind for LSD with either an active or inactive placebo. It must be realized that when attempting to scientifically study such ephemeral and easily influenced processes as those involving human consciousness, methods of study may influence the process and outcome of the research. In 1937 Werner Heisenberg demonstrated the uncertainty principle in relation to any attempt to measure with accuracy the minute processes of electrons in the atom. One must consider the possibility that current tools and methods for studying the effects of LSD are presently so crude as to demonstrate a similar uncertainty principle in LSD research: The methods of measuring actually influence the process under study to such a degree that the results that are garnered are primarily the effects of attempts at measurement. The continuing crisis in psychiatric and psychological treatment demands that the most powerful of the psychoactive drugs cannot simply be shelved and forgotten. The need is too strong to advance knowledge of the role and function of the human mind in health and disease. LSD and similar drugs hold a tremendous promise for humankind if only ways can be found to further understanding of how to use them responsibly and appropriately. Perhaps other societies that have integrated these substances into the very fabric of their social order may offer models. As Silberman (1970) has written: "No approach is more impractical than one which takes the present arrangements and practices as given, asking only 'How can we do what we are doing more effectively?' or 'How can we bring the worst institutions up to the level of the best?' These questions need to be asked to be sure; but one must also realize that best may not be good enough and may, in any case, already be changing."
对LSD研究历史趋势的回顾清楚地表明,LSD及类似药物在心理效应方面过于强大和独特,不能被误认为只是另一类精神活性化合物并以此进行研究。研究人员的理论理解和期望在确定LSD治疗的主观效应和结果方面的重要性是不可否认的。此外,双盲对照研究已被证明是研究LSD的不适当方法,因为无论是使用活性还是非活性安慰剂,都无法为LSD创造有效的盲法。必须认识到,在试图科学地研究诸如涉及人类意识的短暂且易受影响的过程时,研究方法可能会影响研究的过程和结果。1937年,沃纳·海森堡证明了与任何精确测量原子中电子微小过程的尝试相关的不确定性原理。人们必须考虑这样一种可能性,即目前用于研究LSD效应的工具和方法非常粗糙,以至于在LSD研究中表现出类似的不确定性原理:测量方法实际上对所研究的过程产生了如此大的影响,以至于所获得的结果主要是测量尝试的结果。精神病学和心理治疗中持续存在的危机要求不能简单地搁置和遗忘最强大的精神活性药物。推动对人类思维在健康和疾病中的作用和功能的认识的需求太强烈了。如果能找到进一步理解如何负责任和适当地使用LSD及类似药物的方法,它们对人类有着巨大的前景。也许其他已将这些物质融入其社会秩序结构的社会可以提供范例。正如西尔伯曼(1970年)所写:“没有比将当前的安排和做法视为既定事实,只问‘我们如何能更有效地做我们正在做的事情?’或‘我们如何能将最差的机构提升到最好的水平?’更不切实际的方法了。当然,这些问题需要被问到;但人们也必须意识到,最好的可能还不够好,而且无论如何可能已经在变化。”