在二氢喹唑啉中构建新的碳碳键：高价碘（III）介导的C（sp）-C（sp）键官能化
Constructing new bonds to carbon in dihydroquinazolines hypervalent iodine(III)-mediated C(sp)-C(sp) bond functionalization.
作者信息
Carlson Haley M, Marshall Abigail R, Burton Kaylin M, Mosey R Adam
机构信息
Lake Superior State University, 650 W. Easterday Ave., Sault Sainte Marie, MI 49783, USA.
出版信息
Chem Commun (Camb). 2024 Aug 20;60(68):9097-9100. doi: 10.1039/d4cc02412e.
PMID:39108191
Abstract
A hypervalent iodine(III)-mediated C(sp)-C(sp) bond functionalization reaction for the formation of C-C, C-P, and C-H bonds in dihydroquinazolines has been developed. This one-pot method involves successive oxidation of dihydroquinazoline substrates, mesolytic cleavage of a -butyl substituent, and bond formation to a variety of nucleophiles in moderate to high yields.
摘要
已开发出一种用于在二氢喹唑啉中形成碳 - 碳、碳 - 磷和碳 - 氢键的高价碘（III）介导的C（sp）-C（sp）键官能化反应。这种一锅法涉及二氢喹唑啉底物的连续氧化、α-丁基取代基的均裂裂解以及与各种亲核试剂以中等到高产率形成键。
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