铜锌超氧化物歧化酶：酗酒的一种可能生物学标志物（对黑人患者的研究）

Cupro-zinc superoxide dismutase: a possible biologic marker for alcoholism (studies in black patients).

作者信息

Del Villano B C, Tischfield J A, Schacter L P, Stilwil D, Miller S I

出版信息

Alcohol Clin Exp Res. 1979 Oct;3(4):291-6. doi: 10.1111/j.1530-0277.1979.tb05325.x.

DOI:10.1111/j.1530-0277.1979.tb05325.x

Abstract

Cupro-zinc superoxide dismutase (SOD-1) was measured by competition radioimmune assay of erythrocyte lysates of alcoholic and control subjects. Normal amounts of SOD-1 were found in the extract from control subjects (815 ng/mg Hb) and from white alcoholics (874 ng/mg Hb). However, the level of SOD-1 in lysates from black alcoholics (1033 ng/mg Hb) was significantly increased (p = 0.0001, rank sum test) compared with black and white controls. This increase was not related to any other observed hematologic disorder or to any historical, demographic, or laboratory value examined.

摘要

采用竞争放射免疫分析法对酗酒者和对照者的红细胞裂解物进行检测，以测定铜锌超氧化物歧化酶（SOD-1）。在对照者（815 ng/mg血红蛋白）和白人酗酒者（874 ng/mg血红蛋白）的提取物中发现了正常含量的SOD-1。然而，与黑人和白人对照者相比，黑人酗酒者裂解物中SOD-1的水平（1033 ng/mg血红蛋白）显著升高（p = 0.0001，秩和检验）。这种升高与其他观察到的血液系统疾病无关，也与所检查的任何病史、人口统计学或实验室值无关。