慢性酒精中毒患者大脑中的超氧化物歧化酶活性
Superoxide dismutase activity in brains from chronic alcoholics.
作者信息
Marklund S L, Oreland L, Perdahl E, Winblad B
出版信息
Drug Alcohol Depend. 1983 Nov;12(3):209-15. doi: 10.1016/0376-8716(83)90062-5.
CuZn superoxide dismutase (SOD) and Mn SOD activities were analyzed in hypothalamus, nucleus caudatus, hippocampus and cortex gyrus cinguli from 12 chronic alcoholics and from 16 controls. The CuZn SOD activities were slightly lower and the Mn SOD activities were slightly higher in the brain pieces from chronic alcoholics compared to the controls. The slight differences found can hardly be assigned etiological importance in the degenerative processes in brain tissue connected with chronic alcoholism.
对12名慢性酒精中毒者和16名对照者的下丘脑、尾状核、海马和扣带回皮质中的铜锌超氧化物歧化酶（SOD）和锰超氧化物歧化酶活性进行了分析。与对照组相比，慢性酒精中毒者脑切片中的铜锌超氧化物歧化酶活性略低，锰超氧化物歧化酶活性略高。所发现的微小差异在与慢性酒精中毒相关的脑组织退行性变过程中几乎不具有病因学意义。
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