Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.
Age Ageing. 2024 Aug 6;53(8). doi: 10.1093/ageing/afae167.
We aimed to investigate the association between OA and treatment with dementia risk and structural brain abnormalities.
We recruited a total of 466,460 individuals from the UK Biobank to investigate the impact of OA on the incidence of dementia. Among the total population, there were 63,081 participants diagnosed with OA. We subsequently categorised the OA patients into medication and surgery groups based on treatment routes. Cox regression models explored the associations between OA/OA treatment and dementia risk, with the results represented as hazard ratios (HRs) and 95% confidence intervals (95% CI). Linear regression models assessed the associations of OA/OA therapy with alterations in cortical structure.
During an average of 11.90 (± 1.01) years of follow-up, 5,627 individuals were diagnosed with all-cause dementia (ACD), including 2,438 AD (Alzheimer's disease), and 1,312 VaD (vascular dementia) cases. Results revealed that OA was associated with the elevated risk of ACD (HR: 1.116; 95% CI: 1.039-1.199) and AD (HR: 1.127; 95% CI: 1.013-1.254). OA therapy lowered the risk of dementia in both medication group (HR: 0.746; 95% CI: 0.652-0.854) and surgery group (HR: 0.841; 95% CI: 0.736-0.960). OA was negatively associated with cortical area, especially precentral, postcentral and temporal regions.
Osteoarthritis increased the likelihood of developing dementia, and had an association with regional brain atrophy. OA treatment lowered the dementia risk. OA is a promising modifiable risk factor for dementia.
本研究旨在探究骨关节炎（OA）与痴呆风险和结构脑异常之间的关联。
我们共招募了来自英国生物库的 466460 名个体，以探究 OA 对痴呆发病的影响。在总人群中，有 63081 名参与者被诊断为 OA。随后，我们根据治疗途径将 OA 患者分为药物治疗和手术治疗组。Cox 回归模型探讨了 OA/OA 治疗与痴呆风险之间的关联，结果表示为风险比（HR）和 95%置信区间（95%CI）。线性回归模型评估了 OA/OA 治疗与皮质结构改变之间的关联。
在平均 11.90（±1.01）年的随访期间，共有 5627 人被诊断为全因痴呆（ACD），其中包括 2438 例阿尔茨海默病（AD）和 1312 例血管性痴呆（VaD）。结果表明，OA 与 ACD（HR：1.116；95%CI：1.039-1.199）和 AD（HR：1.127；95%CI：1.013-1.254）发病风险升高相关。OA 治疗降低了药物治疗组（HR：0.746；95%CI：0.652-0.854）和手术治疗组（HR：0.841；95%CI：0.736-0.960）的痴呆发病风险。OA 与皮质面积呈负相关，尤其是中央前回、中央后回和颞叶区域。
骨关节炎增加了痴呆的发病风险，与区域性脑萎缩相关。OA 治疗降低了痴呆风险。OA 是痴呆的一个有前途的可改变风险因素。
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