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前额叶皮质中作为视觉工作记忆特征的δ-α/β耦合

Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.

作者信息

Aliramezani Mohammad, Farrokhi Ashkan, Constantinidis Christos, Daliri Mohammad Reza

机构信息

School of Cognitive Sciences (SCS), Institute for Research in Fundamental Sciences (IPM), Tehran 19568-36613, Iran.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

出版信息

iScience. 2024 Jul 3;27(8):110453. doi: 10.1016/j.isci.2024.110453. eCollection 2024 Aug 16.

DOI:10.1016/j.isci.2024.110453
PMID:39108712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300902/
Abstract

Executive functions, particularly visual working memory, depend on the prefrontal cortex (PFC). Phase-amplitude coupling (PAC) has been proposed as a measure of synchronized brain oscillations. To study the neural correlates of working memory in cross-frequency interactions, local field potential (LFP) recordings were made in the PFC of two macaque monkeys. PAC analysis revealed that the delta band (1-5 Hz) phase modulated the alpha-beta band (8-33 Hz) amplitude throughout task epochs, in both the pre- and post-training stages. The elevation of δ-αβ PAC in the fixation period during post-training was a signature of task learning. Interestingly, the δ-αβ PAC was not enhanced in error trials compared to correct trials, and the subject's performance was strictly dependent on the orchestration of the delta phase. Furthermore, contrary to the dorsoventral functional specialization of PFC, spatial and shape stimuli induced the same pattern of PAC in PFC subdivisions.

摘要

执行功能，尤其是视觉工作记忆，依赖于前额叶皮质（PFC）。相位-振幅耦合（PAC）已被提议作为一种同步脑振荡的测量方法。为了研究跨频率相互作用中工作记忆的神经相关性，在两只猕猴的前额叶皮质进行了局部场电位（LFP）记录。PAC分析显示，在训练前和训练后阶段，整个任务时期内，δ波段（1-5赫兹）相位调制了α-β波段（8-33赫兹）的振幅。训练后固定期δ-αβ PAC的升高是任务学习的一个标志。有趣的是，与正确试验相比，错误试验中的δ-αβ PAC没有增强，并且受试者的表现严格依赖于δ相位的协调。此外，与前额叶皮质的背腹功能特化相反，空间和形状刺激在前额叶皮质分区中诱导了相同的PAC模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/d7ed44bb6a61/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/efa32e644271/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/fbd30d434025/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/383e749bfe3f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/62da0496b03a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/2f1a018ece80/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/cbcc6c5c0a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/d7ed44bb6a61/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/efa32e644271/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/fbd30d434025/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/383e749bfe3f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/62da0496b03a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/2f1a018ece80/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/cbcc6c5c0a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg

相似文献

[1]
Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.

iScience. 2024-7-3

[2]
Phase-Amplitude Coupling and Long-Range Phase Synchronization Reveal Frontotemporal Interactions during Visual Working Memory.

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[3]
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[4]
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[5]
Effects of high-frequency transcranial magnetic stimulation on theta-gamma oscillations and coupling in the prefrontal cortex of rats during working memory task.

Med Biol Eng Comput. 2023-12

[6]
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[7]
Phase-amplitude coupling between low-frequency scalp EEG and high-frequency intracranial EEG during working memory task.

J Neural Eng. 2022-4-20

[8]
Concurrent interactions between prefrontal cortex and hippocampus during a spatial working memory task.

Brain Struct Funct. 2022-6

[9]
Intrinsic phase-amplitude coupling on multiple spatial scales during the loss and recovery of consciousness.

Comput Biol Med. 2022-8

[10]
Attention Decreases Phase-Amplitude Coupling, Enhancing Stimulus Discriminability in Cortical Area MT.

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引用本文的文献

[1]
Application of Graph-Theoretic Methods Using ERP Components and Wavelet Coherence on Emotional and Cognitive EEG Data.

Brain Sci. 2025-7-2

[2]
Protocol for phase-amplitude coupling analysis in local field potentials from macaque monkeys to investigate neural oscillation dynamics.

STAR Protoc. 2025-6-23

[3]
Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.

Commun Biol. 2025-5-20

本文引用的文献

[1]
Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions.

Cell Rep. 2023-9-26

[2]
Rhythmic attentional scanning.

Neuron. 2023-4-5

[3]
Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.

PLoS Comput Biol. 2023-3

[4]
Functional connectivity fingerprints of the frontal eye field and inferior frontal junction suggest spatial versus nonspatial processing in the prefrontal cortex.

Eur J Neurosci. 2023-4

[5]
Long-term learning transforms prefrontal cortex representations during working memory.

Neuron. 2022-11-16

[6]
Plasticity after cognitive training reflected in prefrontal local field potentials.

iScience. 2022-8-12

[7]
Dynamic theta-modulated high frequency oscillations in rat medial prefrontal cortex during spatial working memory task.

Physiol Behav. 2022-10-1

[8]
Rhythms in cognition: The evidence revisited.

Eur J Neurosci. 2022-6

[9]
Dynamic coupling of oscillatory neural activity and its roles in visual attention.

Trends Neurosci. 2022-4

[10]
Prefrontal cortical plasticity during learning of cognitive tasks.

Nat Commun. 2022-1-10

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