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前额叶皮质中作为视觉工作记忆特征的δ-α/β耦合

Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.

作者信息

Aliramezani Mohammad, Farrokhi Ashkan, Constantinidis Christos, Daliri Mohammad Reza

机构信息

School of Cognitive Sciences (SCS), Institute for Research in Fundamental Sciences (IPM), Tehran 19568-36613, Iran.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

出版信息

iScience. 2024 Jul 3;27(8):110453. doi: 10.1016/j.isci.2024.110453. eCollection 2024 Aug 16.

DOI:10.1016/j.isci.2024.110453
PMID:39108712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300902/
Abstract

Executive functions, particularly visual working memory, depend on the prefrontal cortex (PFC). Phase-amplitude coupling (PAC) has been proposed as a measure of synchronized brain oscillations. To study the neural correlates of working memory in cross-frequency interactions, local field potential (LFP) recordings were made in the PFC of two macaque monkeys. PAC analysis revealed that the delta band (1-5 Hz) phase modulated the alpha-beta band (8-33 Hz) amplitude throughout task epochs, in both the pre- and post-training stages. The elevation of δ-αβ PAC in the fixation period during post-training was a signature of task learning. Interestingly, the δ-αβ PAC was not enhanced in error trials compared to correct trials, and the subject's performance was strictly dependent on the orchestration of the delta phase. Furthermore, contrary to the dorsoventral functional specialization of PFC, spatial and shape stimuli induced the same pattern of PAC in PFC subdivisions.

摘要

执行功能，尤其是视觉工作记忆，依赖于前额叶皮质（PFC）。相位-振幅耦合（PAC）已被提议作为一种同步脑振荡的测量方法。为了研究跨频率相互作用中工作记忆的神经相关性，在两只猕猴的前额叶皮质进行了局部场电位（LFP）记录。PAC分析显示，在训练前和训练后阶段，整个任务时期内，δ波段（1-5赫兹）相位调制了α-β波段（8-33赫兹）的振幅。训练后固定期δ-αβ PAC的升高是任务学习的一个标志。有趣的是，与正确试验相比，错误试验中的δ-αβ PAC没有增强，并且受试者的表现严格依赖于δ相位的协调。此外，与前额叶皮质的背腹功能特化相反，空间和形状刺激在前额叶皮质分区中诱导了相同的PAC模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/d7ed44bb6a61/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/efa32e644271/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/fbd30d434025/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/383e749bfe3f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/62da0496b03a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/2f1a018ece80/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/cbcc6c5c0a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/d7ed44bb6a61/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/efa32e644271/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/fbd30d434025/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/383e749bfe3f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/62da0496b03a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/2f1a018ece80/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/cbcc6c5c0a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e1/11300902/f83eeff11505/gr7.jpg

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本文引用的文献

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Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions.θ 振荡作为内侧前额叶-海马体集合相互作用的基础。
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Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.海马 CA1 微电路中的θ-γ 相位幅度耦合。
揭示前额叶皮层中空间工作记忆持续神经元和选择性神经元的作用。
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