Singh Balbir, Wang Zhengyang, Qi Xue-Lian, Constantinidis Christos
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Neuroscience Program, Vanderbilt University, Nashville, TN 37235, USA.
iScience. 2022 Aug 12;25(9):104929. doi: 10.1016/j.isci.2022.104929. eCollection 2022 Sep 16.
Learning to perform a new cognitive task induces plasticity of the prefrontal cortex generally involving activation of more neurons and increases in firing rate; however, its effects on single neurons are diverse and complex. We sought to understand how training affects global measures of neural activity by recording and analyzing local field potentials (LFPs) in monkeys before and after they learned to perform working memory tasks. LFP power after training was characterized by a reduction in power in 20-40 Hz during the stimulus presentations and delay periods of the task. Both evoked power, synchronized to task events, and induced power exhibited this decrease after training. The effect was consistent across tasks requiring memory of spatial location and stimulus shape. Error trials were characterized by a lack of LFP power ramping around the fixation onset. Our results reveal signatures of cortical plasticity in LFPs associated with learning to perform cognitive tasks.
学习执行一项新的认知任务会诱导前额叶皮质的可塑性，通常涉及更多神经元的激活以及 firing 率的增加；然而，其对单个神经元的影响是多样且复杂的。我们试图通过记录和分析猴子在学习执行工作记忆任务前后的局部场电位（LFP）来了解训练如何影响神经活动的整体指标。训练后的 LFP 功率表现为在任务的刺激呈现和延迟期内 20 - 40Hz 的功率降低。与任务事件同步的诱发功率和诱导功率在训练后均呈现出这种下降。在需要记忆空间位置和刺激形状的任务中，这种效应是一致的。错误试验的特征是在注视开始时缺乏 LFP 功率斜坡。我们的结果揭示了与学习执行认知任务相关的 LFP 中皮质可塑性的特征。
