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E2F7在癌症中的作用：当前认知与未来展望。

The roles of E2F7 in cancer: Current knowledge and future prospects.

作者信息

Chen Ke-Qian, Lei Hai-Bo, Liu Xiang, Wang Shu-Zhi

机构信息

Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, 411100, China.

Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.

出版信息

Heliyon. 2024 Jul 9;10(14):e34362. doi: 10.1016/j.heliyon.2024.e34362. eCollection 2024 Jul 30.

DOI:10.1016/j.heliyon.2024.e34362
PMID:39108857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11301362/
Abstract

BACKGROUND: E2F7 is a recently discovered member of the E2F family. Investigating the function and mechanism of E2F7 in the growth of tumors is significant for the clinical diagnosis and therapy of these malignancies. OBJECTIVE: The purpose of this review is to provide theoretical basis for the diagnosis and treatment of malignant tumors by exploring E2F7. METHODS: The relevant information was collected through the PubMed database using keyword searches "E2F7" and "cancer". RESULTS: On the one hand, E2F7 plays an essential role in embryonic development, angiogenesis, and the nervous system. On the other hand, E2F7 is also linked to the occurrence and growth of various malignant tumors. CONCLUSION: E2F7 has potential as a therapeutic target in future cancer treatments.

摘要

背景：E2F7是E2F家族最近发现的成员。研究E2F7在肿瘤生长中的功能和机制对这些恶性肿瘤的临床诊断和治疗具有重要意义。 目的：本综述旨在通过探索E2F7为恶性肿瘤的诊断和治疗提供理论依据。 方法：通过PubMed数据库使用关键词“E2F7”和“癌症”收集相关信息。 结果：一方面，E2F7在胚胎发育、血管生成和神经系统中起重要作用。另一方面，E2F7也与各种恶性肿瘤的发生和生长有关。 结论：E2F7在未来癌症治疗中具有作为治疗靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/377e923dd78b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/6ad22746c447/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/590b9319292d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/a6bca3954ea3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/377e923dd78b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/6ad22746c447/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/590b9319292d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/a6bca3954ea3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033d/11301362/377e923dd78b/gr4.jpg

相似文献

[1]
The roles of E2F7 in cancer: Current knowledge and future prospects.

Heliyon. 2024-7-9

[2]
Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

J Biol Chem. 2003-10-24

[3]
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

EMBO J. 2012-8-17

[4]
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes.

EMBO J. 2003-12-1

[5]
Identification of E2F transcription factor 7 as a novel potential biomarker for oral squamous cell carcinoma.

Head Face Med. 2021-2-26

[6]
E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA-383-5p transcription.

Mol Carcinog. 2022-11

[7]
Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients.

Clin Cancer Res. 2007-1-1

[8]
E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.

Medicine (Baltimore). 2024-1-19

[9]
E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.

Genes Dev. 2012-7-15

[10]
DNA-damage response control of E2F7 and E2F8.

EMBO Rep. 2008-3

引用本文的文献

[1]
Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma.

Acta Pharmacol Sin. 2025-3-25

本文引用的文献

[1]
E2F family play important roles in tumorigenesis.

Yi Chuan. 2023-7-20

[2]
E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.

FASEB J. 2023-7

[3]
VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.

J Biol Chem. 2023-5

[4]
Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma.

BMC Med Genomics. 2023-2-28

[5]
Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.

Hum Cell. 2023-3

[6]
E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA-383-5p transcription.

Mol Carcinog. 2022-11

[7]
Comprehensive Analysis of the E2F Transcription Factor Family in Human Lung Adenocarcinoma.

Int J Gen Med. 2022-7-2

[8]
E2F7 promotes mammalian target of rapamycin inhibitor resistance in hepatocellular carcinoma after liver transplantation.

Am J Transplant. 2022-10

[9]
EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC.

NAR Cancer. 2022-5-27

[10]
HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS.

J Oncol. 2022-5-9

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