Wang Xiuyuan, Han Xue, Hu Feifei, Xu Xinzhi, Huang Junxia, Yang Ji
Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Heliyon. 2024 Jul 9;10(14):e34398. doi: 10.1016/j.heliyon.2024.e34398. eCollection 2024 Jul 30.
Linear morphea is the most disabling subtype of morphea, which may cause a series of excutaneous manifestations and sequelae. To futher explore the clinical characteristics of linear morphea, we conducted a retrospective study of 22 patients diagnosed with linear morphea in our department during the past 2 years. Their baseline clinical information, skin manifestations, complications and therapeutic effect were analyzed. Here, we report six cases of a special linear morphea, usually occurring on the unilateral upper limbs of young women, spreading along the distribution of the radial nerve and frequently progressing across the joint, which increases the incidence of neuromusculoskeletal disorders. Instead of traditional topical drugs, a combination of systemic prednisone and methotrexate improved their skin lesions and complications. Recognition of this special type of linear morphea enables earlier diagnosis and active treatment plan, which contributes to ameliorate the symptoms and avoid functional sequelae.
线状硬皮病是硬皮病中最致残的亚型，可导致一系列皮肤表现和后遗症。为进一步探讨线状硬皮病的临床特征，我们对过去2年在我科诊断为线状硬皮病的22例患者进行了回顾性研究。分析了他们的基线临床信息、皮肤表现、并发症及治疗效果。在此，我们报告6例特殊的线状硬皮病病例，通常发生于年轻女性的单侧上肢，沿桡神经分布扩散，且常跨越关节进展，这增加了神经肌肉骨骼疾病的发生率。与传统外用药物不同，系统性泼尼松和甲氨蝶呤联合使用改善了他们的皮肤病变和并发症。认识到这种特殊类型的线状硬皮病有助于早期诊断和制定积极的治疗方案，从而有助于改善症状并避免功能后遗症。
