A Novel Non-invasive Predictor Measure of Left Atrial Pressure and Practical Implicates in High Frequency Ventilation: Theory.

A new prototype of ventilator mode, based on high-frequency ventilation (HFV), aims to address the interrelations among diverse respiratory variables, several intercardiovascular parameters rapports, and instantaneously the intrarespiratory and cardiac interactions. This article proposes a logarithmic network of integrated correlation ratio H/V, R , that primarily relates both dependent respiratory (V) and independent hemodynamic variables (H). Given a constant steady state of the heart and vasculature, a difference between calculated ratio (R calc), and optimized ratio (R opt) could be utilized to adjust many aspects of several parameters and outcomes in critically ill patients. The central venous pressure (CVP) wave analysis aims to approach several cardiovascular parameters, endpoints of left atrial (LA) pressure, and the cardiac output (CO) with the help of thermodilution curve analysis. This might result in several innovative formulas of mathematical base. Their relevant clinical implicates demonstrated a wide area of normalized distribution capacity (Cd), systemic vascular capacity (Cs), pulmonary vascular capacitance (Cp), pulmonary vascular resistance (PVR), and mean pulmonary artery pressure (MPAP). The authors claim that prepared software programming helps network integration of all these variables, feeding back and addressing the prototype of novel mode for the old new application of HFV. One potential unique criterion is adjusting LA and ultimately CO through a feedback control mechanism. Though this all sounds very plausible, the reader must be reminded that everything in this work is based on the most expected speculations and experience and could be potentially different than that in vivo. More importantly, animal experimental studies are warranted.