Kubanek Alicja, Renke Marcin, Godlewska Beata R, Paul Przemysław, Przybylak Mateusz, Kowalska Anna S, Wąż Piotr, Błaszczyk Michał, Macul-Sanewska Aleksandra, Rutkowski Przemysław, Czarnacka Kamila, Bednarski Krzysztof, Grabowski Jakub
Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdańsk, Gdańsk, Poland.
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Front Psychiatry. 2024 Jul 23;15:1410252. doi: 10.3389/fpsyt.2024.1410252. eCollection 2024.
Depressive disorder is common among haemodialysis patients. The purpose of this study was to explore approaches to diagnosing depression in the context of a real-life setting, with the view of creating practical recommendations. It also aimed to evaluate the prevalence of depression and dementia.
We conducted a cross-sectional study in two Dialysis Centres in Poland. Cognitive functions were evaluated using Mini-Mental State Examination (MMSE). The screening for depressive symptoms was assessed using Beck Depression Inventory II (BDI-II). The diagnosis of major depressive disorder was confirmed by a psychiatrist using Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5). Sociodemographic and clinical data were also collected.
Initially, 136 patients agreed to participate in the study. Dementia was found in 13% of the study group. Sixty-two patients did not agree to perform all the proposed tests and were not included in the analysis, which eventually consisted of 70 patients. According to BDI-II, depressive symptoms were present in 35.7% of patients, while the diagnosis of major depressive disorder (MDD) was confirmed by the psychiatrist in 25.7%. According to the ROC analysis the optimal cut-off score for diagnosing MDD using BDI-II was ≥13 points.
This study suggests that the regular screening for depressive symptoms, followed by a psychiatric consultation in selected patients, might improve diagnosing depression with the goal of achieving a higher quality of life and a lower mortality rate. It may also be a cost-effective model for the management of depression among the haemodialysis population.
抑郁症在血液透析患者中很常见。本研究的目的是在现实生活环境中探索诊断抑郁症的方法,以期提出实用建议。研究还旨在评估抑郁症和痴呆症的患病率。
我们在波兰的两个透析中心进行了一项横断面研究。使用简易精神状态检查表(MMSE)评估认知功能。使用贝克抑郁量表第二版(BDI-II)评估抑郁症状筛查情况。由精神科医生依据《精神疾病诊断与统计手册》第5版(DSM-5)确诊重度抑郁症。同时收集社会人口统计学和临床数据。
最初,136名患者同意参与研究。研究组中13%的患者被发现患有痴呆症。62名患者不同意进行所有提议的测试,未纳入分析,最终分析纳入70名患者。根据BDI-II,35.7%的患者存在抑郁症状,而精神科医生确诊重度抑郁症(MDD)的比例为25.7%。根据ROC分析,使用BDI-II诊断MDD的最佳临界值为≥13分。
本研究表明,定期筛查抑郁症状,随后对部分患者进行精神科会诊,可能会改善抑郁症的诊断,目标是提高生活质量和降低死亡率。这也可能是血液透析人群抑郁症管理的一种具有成本效益的模式。