Park Yeong-Won, Hwang Jaeseung, Kim Minsang, Kim Seon-Mi, Jeong Yujin, Kang Minjung, Kang Eunjeong, Ryu Hyunjin, Park Sue K, Kim Yaeni, Jeong Jong Cheol, Han Seung Hyeok, Oh Kook-Hwan
Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Seoul National University College of Medicine, Seoul, Republic of Korea.
Kidney Res Clin Pract. 2025 May;44(3):535-544. doi: 10.23876/j.krcp.23.263. Epub 2024 Jul 25.
Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients' quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade.
This is a prospective cohort study of CKD patients entitled the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). A total of 2,238 patients were examined, and the reasons for hospitalization were classified into 16 disease categories. The incidence rate ratio (IRR) according to CKD stage was compared using negative bimodal regression analysis.
The all-cause hospitalization incidence was 184.96 per 1,000 person-years. The most common reason for hospitalization was circulatory system disease, followed by infection and digestive system disease. Among hospitalizations for acute kidney injury, endocrine-nutrition-metabolic-related illness, blood-related disease, and diseases of the nervous system and sensory organs, IRR increased as CKD grade advanced. The incidence of ophthalmologic surgery during hospitalization increased according to the CKD stage. The IRR of KNOW-CKD patients was 6.19 (95% confidence interval, 5.92-6.48; p < 0.001) compared with the general population.
This in-depth analysis of hospitalizations among CKD patients confirmed that CKD patients were hospitalized for various reasons, such as metabolic, ophthalmic, and hematologic diseases. Early detection and intervention regarding causative diseases of CKD are important to reduce the hospitalization burden and improve patients' quality of life.
慢性肾脏病（CKD）患者因各种病症住院。住院会增加再入院率和死亡率，严重恶化患者的生活质量。因此，根据CKD分级从更广泛的角度分析CKD患者的住院原因至关重要。
这是一项针对CKD患者的前瞻性队列研究，名为韩国慢性肾脏病患者结局队列研究（KNOW-CKD）。共检查了2238例患者，将住院原因分为16种疾病类别。使用负二项回归分析比较根据CKD分期的发病率比（IRR）。
全因住院发病率为每1000人年184.96例。最常见的住院原因是循环系统疾病，其次是感染和消化系统疾病。在因急性肾损伤、内分泌-营养-代谢相关疾病、血液相关疾病以及神经系统和感觉器官疾病住院的患者中，IRR随着CKD分级的进展而增加。住院期间眼科手术的发生率根据CKD分期而增加。与普通人群相比，KNOW-CKD患者的IRR为6.19（95%置信区间，5.92-6.48；p<0.001）。
对CKD患者住院情况的深入分析证实，CKD患者因各种原因住院，如代谢、眼科和血液系统疾病。早期发现和干预CKD的致病疾病对于减轻住院负担和提高患者生活质量很重要。
