Department of Pharmacy, College of Medicine and Health Science, Ambo University, Ambo, Ethiopia.
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
PLoS One. 2019 Feb 27;14(2):e0212184. doi: 10.1371/journal.pone.0212184. eCollection 2019.
Quality of life (QoL) is increasingly being considered as an important measure of how disease affects patients' lives, especially for long-term diseases like chronic kidney disease (CKD). Even though there is no statistically significant association between stages of CKD and QoL, it is decreased in patients with early stages of the disease. Hence, this study aimed to assess QoL and its predictors among patients with CKD at Tikur Anbessa Specialized Hospital (TASH).
A cross sectional study was conducted at the nephrology clinic of TASH. A total of 256 patients were recruited through systematic random sampling. Data were collected using the Medical Outcomes Study Short Form 36-Items (SF-36). The data were entered into Epi Info 7.2.2.2 and analyzed using SPSS version 20.0 statistical software. Descriptive statistics like frequency, percent, mean and standard deviation were used to summarize patients' baseline characteristics. Student's unpaired t-test and ANOVA were conducted to compare two groups and more than two groups in the analysis of QoL, respectively. Multivariable linear regression was employed to investigate the potential predictors of QoL.
Quality of life was decreased in all stages of CKD. A reduction in physical functioning (p = 0.03), bodily pain (p = 0.004), vitality (p = 0.019) and social functioning (p = 0.002) was observed progressively across stages of CKD. High income status and greater than 11g/dl hemoglobin level were found to be predictors of all high score SF-36 domains. High family income (β 15.33; 95%CI: 11.33-19.33, p<0.001), higher educational status (β 7.9; 95%CI: 4.10-11.66, p<0.001), and hemoglobin ≥11g/dl (β 8.36; 95%CI: 6.31-10.41, p<0.001) were predictors of better QoL in the physical component summary, whereas absence of CKD complications (β 2.75; 95%CI: 0.56-4.94, p = 0.014), high family income (β 10.10; 95%CI: 5.10-15.10, p<0.001) and hemoglobin ≥11g/dl (β 4.54, 95%CI: 2.01-7.08, p = 0.001) were predictors of better QoL in the mental component summary.
In this setting, QoL decreased in CKD patients in the early stages of the disease. Study participants with low income and hemoglobin level were considered to have worse quality of life in both physical and mental component summaries.
生活质量（QoL）越来越被视为衡量疾病如何影响患者生活的重要指标，尤其是对于慢性肾脏病（CKD）等长期疾病。尽管 CKD 分期与 QoL 之间没有统计学上的显著关联，但在疾病早期患者的 QoL 就已经降低。因此，本研究旨在评估提格雷安巴塞萨专科医院（TASH）CKD 患者的 QoL 及其预测因素。
在 TASH 的肾病科进行了一项横断面研究。通过系统随机抽样共招募了 256 名患者。使用医疗结局研究短表单 36 项（SF-36）收集数据。数据输入 Epi Info 7.2.2.2 并使用 SPSS 版本 20.0 统计软件进行分析。使用频率、百分比、平均值和标准差等描述性统计方法总结患者的基线特征。学生的独立样本 t 检验和 ANOVA 分别用于比较 QoL 分析中的两组和三组以上。采用多变量线性回归分析探讨 QoL 的潜在预测因素。
所有 CKD 阶段的 QoL 均下降。观察到随着 CKD 分期的进展，身体机能（p=0.03）、身体疼痛（p=0.004）、活力（p=0.019）和社会功能（p=0.002）逐渐下降。高收入状况和血红蛋白水平大于 11g/dl 被发现是所有高 SF-36 评分领域的预测因素。高家庭收入（β 15.33；95%CI：11.33-19.33，p<0.001）、较高的教育程度（β 7.9；95%CI：4.10-11.66，p<0.001）和血红蛋白≥11g/dl（β 8.36；95%CI：6.31-10.41，p<0.001）是身体成分综合评分中 QoL 更好的预测因素，而 CKD 并发症的不存在（β 2.75；95%CI：0.56-4.94，p=0.014）、高家庭收入（β 10.10；95%CI：5.10-15.10，p<0.001）和血红蛋白≥11g/dl（β 4.54，95%CI：2.01-7.08，p=0.001）是心理成分综合评分中 QoL 更好的预测因素。
在本研究中，CKD 患者在疾病早期阶段的 QoL 下降。收入和血红蛋白水平较低的研究参与者被认为在身体和心理成分综合评分中生活质量较差。
