Department of Paediatrics, University of Melbourne, Melbourne, 3010, Australia.
Department of General Practice, Melbourne Medical School, University of Melbourne, Melbourne, 3010, Australia.
Pharmacogenomics. 2024;25(8-9):377-389. doi: 10.1080/14622416.2024.2382078. Epub 2024 Aug 7.
To explore general practitioners' (GPs) views on implementing pharmacogenomic testing in Australian general practice. Semi-structured interviews were conducted with nine GPs in Australia, recruited from primary care networks. Interviews were analyzed using thematic analysis. Themes were mapped onto the Consolidated Framework for Implementation Research domains. Barriers to implementation included lack of knowledge, education, standardized pharmacogenomic reports and national clinical guidelines and financial inaccessibility. Facilitators included positive exposure to pharmacogenomics, peer influences, interdisciplinary collaboration and proven clinical utility. Current uptake was minimal; however, GPs shared positive perceptions of clinical use. Recommendations for successful implementation include building and disseminating clinical evidence, developing national guidelines and standardized reports, incorporation into formal education and increasing financial accessibility.
探讨全科医生（GPs）在澳大利亚全科医学中实施药物基因组学检测的看法。
从初级保健网络中招募了 9 名澳大利亚全科医生进行半结构式访谈。采用主题分析方法对访谈内容进行分析。将主题映射到实施研究领域的综合框架上。实施障碍包括缺乏知识、教育、标准化的药物基因组学报告和国家临床指南以及经济上的不可及性。促进因素包括对药物基因组学的积极接触、同行影响、跨学科合作和已证实的临床实用性。目前的采用率很低；然而，全科医生对临床应用有积极的看法。成功实施的建议包括建立和传播临床证据，制定国家指南和标准化报告，纳入正式教育并增加经济可及性。
