Lee Jaewook
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Korea.
Brain Tumor Res Treat. 2024 Jul;12(3):153-161. doi: 10.14791/btrt.2024.0027.
Extracellular vesicles are nano-sized vesicles surrounded by lipid bilayers, and all cells release them to the extracellular environment for communication. Extracellular vesicles consist of molecules with various biological activities and can play essential roles as therapeutics, so they attract much attention as next-generation modalities to treat various diseases. As extracellular vesicles are cell-derived nanovesicles, they are favorable to be developed as therapeutics, but they also have limitations. In addition, there are a number of things to consider in terms of manufacturing, quality control, non-clinical studies, and clinical trials during the development of extracellular vesicle-based therapeutics. Meanwhile, as much attention has been paid to the potentials of extracellular vesicles as therapeutics, many biopharmaceutical companies are trying to develop extracellular vesicle-based therapeutics. This review will introduce the advantages and limitations of extracellular vesicles as therapeutics. In addition, it will cover things to consider during developing extracellular vesicle-based therapeutics and development cases of extracellular vesicle-based therapeutics.
细胞外囊泡是由脂质双层包围的纳米级囊泡，所有细胞都会将它们释放到细胞外环境中用于通讯。细胞外囊泡由具有各种生物活性的分子组成，并且可以作为治疗剂发挥重要作用，因此作为治疗各种疾病的下一代模式备受关注。由于细胞外囊泡是细胞衍生的纳米囊泡，它们有利于被开发为治疗剂，但它们也有局限性。此外，在基于细胞外囊泡的治疗剂开发过程中，在制造、质量控制、非临床研究和临床试验方面有许多需要考虑的事情。与此同时，由于细胞外囊泡作为治疗剂的潜力受到了广泛关注，许多生物制药公司都在尝试开发基于细胞外囊泡的治疗剂。本综述将介绍细胞外囊泡作为治疗剂的优势和局限性。此外，它将涵盖在开发基于细胞外囊泡的治疗剂过程中需要考虑的事项以及基于细胞外囊泡的治疗剂的开发案例。
