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朱顶红块茎提取物通过调节氧化应激和 TNF-α 炎症通路保护链脲佐菌素诱导的糖尿病肾病大鼠模型的糖尿病肾病。

Amorphophallus campanulatus tuber extract protects diabetic nephropathy in streptozotocin-induced diabetic nephropathy rat model by regulating oxidative stress and TNF-α inflammatory pathway.

机构信息

Xi'an XD Group Hospital - Department of Nephrology - Xi'an, China.

Air Force Medical University - The Third Affiliated Hospital - Department of Geriatrics - Xi'an, China.

出版信息

Acta Cir Bras. 2024 Aug 5;39:e395324. doi: 10.1590/acb395324. eCollection 2024.

DOI:10.1590/acb395324
PMID:39109782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11299378/
Abstract

PURPOSE

To assess the effect of Amorphophallus campanulatus tuber (Ac) extract in the protection of diabetic nephropathy in streptozotocin (STZ) induced diabetic nephropathy (DN) rat model.

METHODS

Diabetes was induced with STZ (60 mg/kg, i.p.), and DN was confirmed after six weeks of STZ administration with the estimation of kidney function test. Further rats were treated with Ac 250 and 500 mg/kg p.o. for next four week. Oxidative stress and level of inflammatory cytokines were estimated in the kidney tissue of DN rats. Histopathology of kidney tissue was performed using hematoxylin and eosin staining.

RESULTS

There was improvement in the body weight of Ac treated groups than DN group of rats. Blood glucose level was observed to be reduced in Ac treated groups than DN group on 42nd and 70th day of protocol. Treatment with Ac ameliorated the altered level of kidney function tests (creatinine and BUN), enzymes of liver function (aspartate aminotransferase and alanine aminotransferase), and lipid profile in the serum of DN rats. Oxidative stress parameters (malondialdehyde and reactive oxygen species enhances and reduction in the level of glutathione and superoxide dismutase) and inflammatory cytokines such as interleukin-6, tumour necrosis factor-α, and monocyte chemoattractant protein-1 reduces in the tissue of Ac treated group than DN group. Treatment with Ac also attenuates the altered histopathological changes in the kidney tissue of DN rats.

CONCLUSIONS

The report suggests that Ac protects renal injury in DN rats by regulating inflammatory cytokines and oxidative stress.

摘要

目的

评估魔芋根茎提取物（Ac）在保护链脲佐菌素（STZ）诱导的糖尿病肾病（DN）大鼠模型中糖尿病肾病的作用。

方法

用 STZ（60mg/kg，腹腔注射）诱导糖尿病，六周后通过肾功能试验评估确定糖尿病肾病。进一步用 Ac 250 和 500mg/kg 灌胃处理 4 周。在 DN 大鼠的肾脏组织中评估氧化应激和炎症细胞因子水平。使用苏木精和伊红染色对肾脏组织进行组织病理学检查。

结果

与 DN 组大鼠相比，Ac 处理组大鼠体重有所改善。在第 42 天和第 70 天的方案中，与 DN 组大鼠相比，Ac 处理组大鼠的血糖水平降低。Ac 治疗改善了 DN 大鼠血清中肾功能试验（肌酐和 BUN）、肝功能（天冬氨酸氨基转移酶和丙氨酸氨基转移酶）和血脂谱的改变。在 Ac 处理组中，氧化应激参数（丙二醛和活性氧增加，谷胱甘肽和超氧化物歧化酶减少）和炎症细胞因子如白细胞介素-6、肿瘤坏死因子-α和单核细胞趋化蛋白-1 的水平降低，比 DN 组大鼠。Ac 治疗还可减轻 DN 大鼠肾脏组织的改变组织病理学变化。

结论

该报告表明，Ac 通过调节炎症细胞因子和氧化应激来保护糖尿病肾病大鼠的肾损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/c6f83297cb4c/1678-2674-acb-39-e395324-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/420cce6552df/1678-2674-acb-39-e395324-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/28a6e977e3bf/1678-2674-acb-39-e395324-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/f9499893144e/1678-2674-acb-39-e395324-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/e7d298b1b76c/1678-2674-acb-39-e395324-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/a5d97646bc2f/1678-2674-acb-39-e395324-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/e84d0bede43f/1678-2674-acb-39-e395324-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/c6f83297cb4c/1678-2674-acb-39-e395324-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/420cce6552df/1678-2674-acb-39-e395324-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/28a6e977e3bf/1678-2674-acb-39-e395324-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/f9499893144e/1678-2674-acb-39-e395324-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/e7d298b1b76c/1678-2674-acb-39-e395324-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/a5d97646bc2f/1678-2674-acb-39-e395324-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/e84d0bede43f/1678-2674-acb-39-e395324-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff13/11299378/c6f83297cb4c/1678-2674-acb-39-e395324-gf07.jpg

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本文引用的文献

1
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Front Endocrinol (Lausanne). 2023 Apr 4;14:1124367. doi: 10.3389/fendo.2023.1124367. eCollection 2023.
2
Role of Macrophages and Related Cytokines in Kidney Disease.巨噬细胞及相关细胞因子在肾脏疾病中的作用。
Front Med (Lausanne). 2021 Jul 8;8:688060. doi: 10.3389/fmed.2021.688060. eCollection 2021.
3
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis.
活性氧诱导的细胞凋亡、自噬和铁死亡中的脂质过氧化作用。
Oxid Med Cell Longev. 2019 Oct 13;2019:5080843. doi: 10.1155/2019/5080843. eCollection 2019.
4
Diabetic kidney disease: world wide difference of prevalence and risk factors.糖尿病肾病：全球患病率及危险因素的差异
J Nephropharmacol. 2015 Oct 9;5(1):49-56. eCollection 2016.
5
Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats.魔芋块茎对大鼠实验性溃疡性结肠炎的有益作用。
Pharm Biol. 2017 Dec;55(1):53-62. doi: 10.1080/13880209.2016.1226904. Epub 2016 Sep 7.
6
Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences.肾病综合征中的脂质代谢紊乱：机制与后果
Kidney Int. 2016 Jul;90(1):41-52. doi: 10.1016/j.kint.2016.02.026. Epub 2016 Apr 26.
7
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Oxid Med Cell Longev. 2016;2016:3164734. doi: 10.1155/2016/3164734. Epub 2016 Jan 10.
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