Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Front Endocrinol (Lausanne). 2023 Apr 4;14:1124367. doi: 10.3389/fendo.2023.1124367. eCollection 2023.
Diabetic nephropathy is a leading cause of end-stage renal disease. The diagnostic markers of nephropathy, including the presence of albuminuria and/or a reduced estimated glomerular filtration rate, are not clinically ideal, and most of them are raised after a significant reduction in renal function. Therefore, it is crucial to seek more sensitive and non-invasive biomarkers for the diagnosis of diabetic nephropathy.
This study aimed to investigate the serum cystatin C levels and dyslipidemia for the detection of diabetic nephropathy in patients with type 2 diabetes mellitus.
A hospital-based comparative cross-sectional study was conducted from December 2021 to August 2022 in Tikur, Anbessa specialized teaching hospital with a sample size of 140 patients with type2 diabetes mellitus. Socio-demographic data was collected using a structured questionnaire, and 5 mL of blood was collected from each participant following overnight fasting for biochemical analyses.
In type 2 diabetes patients with nephropathy, we found significant lipoprotein abnormalities and an increase in serum cystatin C (P < 0.001) compared to those without nephropathy. Serum cystatin C, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, very low-density lipoprotein, high density lipoprotein, and duration of diabetes were identified as being significantly associated with diabetic nephropathy (P < 0.05) in multivariable logistic regression analysis. The mean values of total cholesterol levels, triglyceride levels, and high-density lipoprotein cholesterol levels were also found to be significantly higher (P < 0.05) in females as compared to male type-2 diabetic patients. The fasting blood glucose levels and lipid profiles of the participants were found to be significantly associated with serum cystatin C levels.
The present study found significant serum cystatin C and lipoprotein abnormalities in T2DM patients with diabetic nephropathy when compared with those without diabetic nephropathy, and these lipoprotein abnormalities were significantly associated with serum cystatin C levels.
糖尿病肾病是终末期肾病的主要原因。肾病的诊断标志物，包括白蛋白尿和/或估计肾小球滤过率降低，在临床上并不理想，而且大多数标志物在肾功能明显下降后才会升高。因此，寻找更敏感和非侵入性的生物标志物来诊断糖尿病肾病至关重要。
本研究旨在探讨血清胱抑素 C 水平和血脂异常在 2 型糖尿病患者糖尿病肾病检测中的作用。
一项基于医院的横断面对比研究于 2021 年 12 月至 2022 年 8 月在提克里州安贝斯专业教学医院进行，样本量为 140 例 2 型糖尿病患者。采用结构化问卷收集社会人口学数据，每位参与者在禁食过夜后采集 5 毫升血液进行生化分析。
在患有肾病的 2 型糖尿病患者中，与无肾病患者相比，我们发现脂蛋白异常和血清胱抑素 C 升高具有显著意义（P < 0.001）。多变量逻辑回归分析显示，血清胱抑素 C、收缩压、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、极低密度脂蛋白、高密度脂蛋白和糖尿病病程与糖尿病肾病显著相关（P < 0.05）。在多变量逻辑回归分析中，还发现女性的总胆固醇水平、甘油三酯水平和高密度脂蛋白胆固醇水平的平均值明显高于男性（P < 0.05）。此外，参与者的空腹血糖水平和血脂谱与血清胱抑素 C 水平显著相关。
与无糖尿病肾病的 2 型糖尿病患者相比，本研究发现患有糖尿病肾病的 2 型糖尿病患者的血清胱抑素 C 和脂蛋白异常显著，且这些脂蛋白异常与血清胱抑素 C 水平显著相关。
