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极低尼古丁含量香烟和尼古丁雾化装置特性对早期青年成年人吸烟、雾化或戒烟选择的影响。

Effects of Very Low Nicotine Content Cigarettes and Nicotine Vaping Device Characteristics on Choices to Smoke, Vape, or Abstain in Early Young Adults.

作者信息

Cassidy Rachel N, Tidey Jennifer W, Bello Mariel S, Denlinger-Apte Rachel, Goodwin Christine, Godin Julissa, Cioe Patricia A, Swift Robert, Demorest Connor, Koopmeiners Joseph S, Donny Eric, Hatsukami Dorothy, Colby Suzanne M

机构信息

Center for Alcohol and Addiction Studies, Brown University School of Public Health Providence, RI, USA.

Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

出版信息

Nicotine Tob Res. 2025 Jan 22;27(2):244-253. doi: 10.1093/ntr/ntae194.

Abstract

INTRODUCTION

A national nicotine reduction policy could reduce the public health toll of smoking. However, reducing nicotine in cigarettes may lead to changes in the use of other tobacco products such as nicotine vaping devices, particularly among young people. Product use outcomes may depend on the characteristics of available nicotine vaping devices. We aimed to determine the impact of cigarette nicotine content, vaping device nicotine concentration, and vaping device flavors on choices to smoke, vape, or abstain.

AIMS AND METHODS

Early young adults (ages 18-20 inclusive, N = 80) who reported smoking daily and vaping nicotine at least twice in their lifetime participated in a laboratory study. Participants received either very low nicotine content (VLNC; 0.4 mg nicotine/g of tobacco) or normal nicotine content (NNC; 15.8 mg/g) cigarettes. First, participants chose between their assigned cigarette or abstaining. Subsequently, participants chose between 2 cigarette puffs, 2 vape puffs, or abstaining. Vaping device nicotine concentration (3 mg vs. 18 mg/mL) and flavor (tobacco vs. non-tobacco) were manipulated within subjects.

RESULTS

When only cigarettes were available, there were no differences between the VLNC and NNC groups on cigarette choices. When the nicotine vaping device was concurrently available, the VLNC group made fewer choices to smoke than the NNC group. Non-tobacco flavors and lower vaping device nicotine concentration were associated with fewer choices to smoke.

CONCLUSIONS

Nicotine vaping device availability reduced choices to smoke VLNC cigarettes, and vaping devices with lower nicotine and non-tobacco flavors led to the fewest choices to smoke. Regulators should consider that the availability and characteristics of alternative tobacco products can moderate the product standard's impact.

IMPLICATIONS

The U.S. Food and Drug Administration may enact a reduced nicotine product standard that would affect all commercially available cigarettes. One important population affected by this policy would be early young adults who smoke. We aimed to determine the impact of cigarette nicotine content, vaping device nicotine concentration, and vaping device flavors on choices to smoke, vape, or abstain. Lower nicotine in cigarettes, along with non-tobacco flavors and lower nicotine concentration in the vaping device, were associated with the fewest choices to smoke. Regulators should consider that the availability and characteristics of alternative tobacco products can moderate the product standard's impact.

摘要

引言

一项全国性的尼古丁减量政策可能会降低吸烟对公众健康造成的损害。然而,降低卷烟中的尼古丁含量可能会导致其他烟草产品(如尼古丁电子烟设备)的使用发生变化,尤其是在年轻人当中。产品使用结果可能取决于现有尼古丁电子烟设备的特性。我们旨在确定卷烟尼古丁含量、电子烟设备尼古丁浓度以及电子烟设备口味对吸烟、吸电子烟或戒烟选择的影响。

目的和方法

报告每日吸烟且一生中至少吸过两次尼古丁电子烟的早期青年成年人(年龄在18至20岁之间,包括20岁,N = 80)参与了一项实验室研究。参与者收到的要么是极低尼古丁含量(VLNC;0.4毫克尼古丁/克烟草)的卷烟,要么是正常尼古丁含量(NNC;15.8毫克/克)的卷烟。首先,参与者在分配给他们的卷烟和戒烟之间做出选择。随后,参与者在两口卷烟、两口电子烟或戒烟之间做出选择。电子烟设备尼古丁浓度(3毫克/毫升与18毫克/毫升)和口味(烟草味与非烟草味)在受试者内部进行了操控。

结果

当只有卷烟可供选择时,VLNC组和NNC组在卷烟选择上没有差异。当尼古丁电子烟设备同时可供选择时,VLNC组选择吸烟的次数比NNC组少。非烟草口味和较低的电子烟设备尼古丁浓度与较少的吸烟选择相关。

结论

尼古丁电子烟设备的可用性降低了吸VLNC卷烟的选择,而尼古丁含量较低且为非烟草口味的电子烟设备导致的吸烟选择最少。监管机构应考虑到替代烟草产品的可用性和特性会缓和产品标准的影响。

启示

美国食品药品监督管理局可能会颁布一项降低尼古丁的产品标准,这将影响所有市面上可买到的卷烟。受该政策影响的一个重要群体将是吸烟的早期青年成年人。我们旨在确定卷烟尼古丁含量、电子烟设备尼古丁浓度以及电子烟设备口味对吸烟、吸电子烟或戒烟选择的影响。卷烟中较低的尼古丁含量,以及电子烟设备中的非烟草口味和较低的尼古丁浓度,与最少的吸烟选择相关。监管机构应考虑到替代烟草产品的可用性和特性会缓和产品标准的影响。

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