比较土木香（Zarawand Mudaharaj）和宽叶羌活（Qust）治疗原发性痛经的疗效：一项单盲随机临床试验。

Comparative Efficacy of Aristolochia rotunda L. (Zarawand Mudaharaj) and Saussurea lappa C.B. Clarke (Qust) in Primary Dysmenorrhea--A Single-Blind Randomized Clinical Study.

出版信息

Altern Ther Health Med. 2024 Aug;30(8):6-14.

Abstract

BACKGROUND

The use of plant medications in Unani medicine has been suggested to alleviate pain and related symptoms associated with primary dysmenorrhea, thus enhancing the overall quality of life. The purpose of the current study was to evaluate and compare the efficacy of Zarawand Mudaharaj (Aristolochia rotunda L.) and Qust (Saussurea lappa C.B. Clarke) in treating primary dysmenorrhea.

METHODS

This single-blind, randomized comparative study was conducted on patients with primary dysmenorrhea aged 18-35 years. The study participants were randomly allocated into Group A and Group B. Group A received Zarawand Mudaharaj 2 g twice daily with 5 mL honey while Group B received Qust 1.5 g twice daily with 5 mL honey from the 1st to the 5th day of their menstrual cycles for three consecutive cycles. The primary outcome measures were changes in pain severity measured on a 10 cm Visual Analog Scale (VAS) and changes in Verbal Multidimensional Scoring System (VMSS) grades. The secondary outcome measures included changes in Health-Related Quality of Life (HRQoL) measured on short form health survey-12 (SF-12) and changes in the symptoms such as pain during menstruation, low-backache, nausea, vomiting, diarrhoea, giddiness, and headache.

RESULTS

Both groups showed a significant improvement in VMSS grade at all follow-ups compared to baseline (P < .0001). Group B showed better performance than Group A in changing the VMSS grade at the third cycle (P = .02) and the final follow-up (P = .002). Group B also had a more significant reduction in mean ± SD VAS score from baseline (6.43 ± 1.57) to the final follow-up (2.67 ± 1.69) (P < .0001) compared to Group A.

CONCLUSION

The preliminary findings of the study support the use of Zarawand Mudaharaj and Qust in the treatment of primary dysmenorrhea, which is consistent with the traditional knowledge of Unani scholars.

摘要

背景

在顺势疗法中使用植物药物已被证明可以缓解原发性痛经相关的疼痛和相关症状，从而提高整体生活质量。本研究的目的是评估和比较 Zarawand Mudaharaj（马兜铃科植物）和 Qust（菊科植物）治疗原发性痛经的疗效。

方法

这是一项单盲、随机对照研究，纳入了 18-35 岁的原发性痛经患者。研究参与者被随机分配到 A 组和 B 组。A 组在月经周期的第 1 至第 5 天，每天两次服用 Zarawand Mudaharaj 2 克，并用 5 毫升蜂蜜送服；B 组在月经周期的第 1 至第 5 天，每天两次服用 Qust 1.5 克，并用 5 毫升蜂蜜送服，连续服用三个周期。主要结局指标是 10cm 视觉模拟量表（VAS）上疼痛严重程度的变化和言语多维评分系统（VMSS）等级的变化。次要结局指标包括简短健康调查-12（SF-12）健康相关生活质量（HRQoL）的变化和月经期间疼痛、下腰痛、恶心、呕吐、腹泻、头晕和头痛等症状的变化。

结果

与基线相比，两组在所有随访时 VMSS 等级均显著改善（P<0.0001）。与 A 组相比，B 组在第 3 周期（P=0.02）和最终随访（P=0.002）时 VMSS 等级的变化更显著。与 A 组相比，B 组的 VAS 评分从基线（6.43±1.57）到最终随访（2.67±1.69）的平均差值更显著（P<0.0001）。