Department of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.
Lanzhou University of Technology, Lanzhou, 730000, Gansu, China.
Arch Dermatol Res. 2024 Aug 7;316(8):505. doi: 10.1007/s00403-024-03256-x.
This study aimed to analyze the efficacy and safety of microneedling (MN), both alone and in combination with other treatments, to refine the approach for treating acne scars using MN. We systematically searched Pubmed, Cochrane Library, Embase, and Web of Science for randomized controlled trials examining MN or its combinations in patients with acne scars. All statistical analyses were performed using Stata 18 software. A total of 24 studies involving 1546 participants were included. The analysis revealed that MN combined with chemical peels (CP) exhibited the best results in terms of degree of improvement, patient satisfaction, and treatment efficacy compared to other treatments examined, including MN alone, MN with hyaluronic acid (HA), MN with botulinum toxin‑A (TA), MN with platelet-rich plasma (PRP), PRP alone, CP, and laser therapy. The results for MN combined with additional treatments were obviously better than for MN alone. Side effects such as erythema, pain, and post-inflammatory hyperpigmentation showed no significant differences across all treatments assessed.
本研究旨在分析微针（MN）单独使用和联合其他治疗方法的疗效和安全性，以优化 MN 治疗痤疮瘢痕的方法。我们系统地检索了 Pubmed、Cochrane Library、Embase 和 Web of Science 中关于 MN 或其联合治疗痤疮瘢痕患者的随机对照试验。所有统计分析均使用 Stata 18 软件进行。共纳入 24 项研究，涉及 1546 名参与者。分析结果显示，与单独使用 MN、MN 联合透明质酸（HA）、MN 联合肉毒毒素 A（TA）、MN 联合富血小板血浆（PRP）、PRP 单独使用、化学焕肤（CP）和激光治疗相比，MN 联合 CP 在改善程度、患者满意度和治疗效果方面表现最佳。与单独使用 MN 相比，联合其他治疗方法的效果明显更好。所有评估的治疗方法中，红斑、疼痛和炎症后色素沉着等不良反应无显著差异。
