Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Sci Adv. 2024 Aug 9;10(32):eadn5181. doi: 10.1126/sciadv.adn5181. Epub 2024 Aug 7.
Episodic memory in older adults is varied and perceived to rely on numbers of synapses or dendritic spines. We analyzed 2157 neurons among 128 older individuals from the Religious Orders Study and Rush Memory and Aging Project. Analysis of 55,521 individual dendritic spines by least absolute shrinkage and selection operator regression and nested model cross-validation revealed that the dendritic spine head diameter in the temporal cortex, but not the premotor cortex, improved the prediction of episodic memory performance in models containing β amyloid plaque scores, neurofibrillary tangle pathology, and sex. These findings support the emerging hypothesis that, in the temporal cortex, synapse strength is more critical than quantity for memory in old age.
老年人的情景记忆是多样的，被认为依赖于突触或树突棘的数量。我们分析了来自宗教秩序研究和 Rush 记忆与衰老项目的 128 名老年人中的 2157 个神经元。通过最小绝对值收缩和选择算子回归以及嵌套模型交叉验证分析了 55521 个单独的树突棘，结果表明，颞叶皮层的树突棘头直径而不是运动前皮层，可改善包含β淀粉样斑块评分、神经原纤维缠结病理和性别的模型中情景记忆表现的预测。这些发现支持了一个新兴的假设，即在颞叶皮层中，突触强度比数量对于老年人的记忆更为关键。
