Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA.
Dev Cogn Neurosci. 2024 Oct;69:101427. doi: 10.1016/j.dcn.2024.101427. Epub 2024 Aug 3.
Traumatic brain injury (TBI) and potentially traumatic events (PTEs) contribute to increased substance use, mental health issues, and cognitive impairments. However, there's not enough research on how TBI and PTEs combined impact mental heath, substance use, and neurocognition.
This study leverages a subset of The National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) multi-site dataset with 551 adolescents to assess the combined and distinctive impacts of TBI, PTEs, and TBI+PTEs (prior to age 18) on substance use, mental health, and neurocognitive outcomes at age 18.
TBI, PTEs, and TBI+PTEs predicted greater lifetime substance use and past-year alcohol and cannabis use. PTEs predicted greater internalizing symptoms, while TBI+PTEs predicted greater externalizing symptoms. Varying effects on neurocognitive outcomes included PTEs influencing attention accuracy and TBI+PTEs predicting faster speed in emotion tasks. PTEs predicted greater accuracy in abstraction-related tasks. Associations with working memory were not detected.
This exploratory study contributes to the growing literature on the complex interplay between TBI, PTEs, and adolescent mental health, substance use, and neurocognition. The developmental implications of trauma via TBIs and/or PTEs during adolescence are considerable and worthy of further investigation.
创伤性脑损伤（TBI）和潜在创伤性事件（PTEs）会导致更多的物质使用、心理健康问题和认知障碍。然而，关于 TBI 和 PTEs 结合如何影响心理健康、物质使用和神经认知的研究还不够充分。
本研究利用国家青少年酒精和神经发育联合中心（NCANDA）多地点数据集的一个子集，对 551 名青少年进行评估，以研究 TBI、PTEs 以及 TBI+PTEs（在 18 岁之前）对 18 岁时物质使用、心理健康和神经认知结果的综合和独特影响。
TBI、PTEs 和 TBI+PTEs 预测了更高的终生物质使用和过去一年的酒精和大麻使用。PTEs 预测了更多的内在症状，而 TBI+PTEs 则预测了更多的外在症状。对神经认知结果的影响也不同，包括 PTEs 影响注意力准确性，而 TBI+PTEs 预测情绪任务中的更快速度。PTEs 预测了抽象相关任务中的更高准确性。没有检测到与工作记忆的关联。
这项探索性研究为不断增长的关于 TBI、PTEs 和青少年心理健康、物质使用和神经认知之间复杂相互作用的文献做出了贡献。青少年时期通过 TBI 和/或 PTEs 发生创伤的发展影响是相当大的，值得进一步研究。
