Columbia University, New York; New York State Psychiatric Institute, New York.
Columbia University, New York.
J Am Acad Child Adolesc Psychiatry. 2017 Sep;56(9):755-764.e3. doi: 10.1016/j.jaac.2017.06.006. Epub 2017 Jul 4.
Exposure to violence and other forms of potentially traumatic events (PTEs) are common among youths with externalizing psychopathology. These associations likely reflect both heightened risk for the onset of externalizing problems in youth exposed to PTEs and elevated risk for experiencing PTEs among youth with externalizing disorders. In this study, we disaggregate the associations between exposure to PTEs and externalizing disorder onset in a population-representative sample of adolescents.
We analyzed data from 13- to 18-year-old participants in the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A) (N = 6,379). Weighted survival models estimated hazard ratios (HRs) for onset of oppositional defiant disorder (ODD), conduct disorder (CD), and substance use disorders (SUDs) associated with PTEs, and for exposure to PTEs associated with prior-onset externalizing disorders. Multiplicative interaction terms tested for effect modification by sex, race/ethnicity, and household income.
All types of PTEs were associated with higher risk for SUD (HRs = 1.29-2.21), whereas only interpersonal violence (HR = 2.49) was associated with onset of CD and only among females. No associations were observed for ODD. Conversely, ODD and CD were associated with elevated risk for later exposure to interpersonal violence and other/nondisclosed events (HRs = 1.45-1.75).
Externalizing disorders that typically begin in adolescence, including SUDs and CD, are more likely to emerge in adolescents with prior trauma. ODD onset, in contrast, is unrelated to trauma exposure but is associated with elevated risk of experiencing trauma later in development. CD and interpersonal violence exposure exhibit reciprocal associations. These findings have implications for interventions targeting externalizing and trauma-related psychopathology.
暴露于暴力和其他形式的潜在创伤性事件(PTEs)在患有外化性精神病理学的年轻人中很常见。这些关联可能既反映了 PTEs 暴露后年轻人外化问题发病风险的增加,也反映了患有外化障碍的年轻人经历 PTEs 的风险增加。在这项研究中,我们在一个具有代表性的青少年人群中,将 PTEs 暴露与外化障碍发病分开来进行分析。
我们分析了来自国家共病调查复制-青少年补充调查(NCS-A)(N=6379)的 13 至 18 岁参与者的数据。加权生存模型估计了与 PTEs 相关的对立违抗性障碍(ODD)、品行障碍(CD)和物质使用障碍(SUD)发病的风险比(HR),以及与先前发病的外化障碍相关的 PTEs 暴露的 HR。乘法交互项检验了性别、种族/民族和家庭收入的调节作用。
所有类型的 PTEs 都与 SUD 的发病风险增加相关(HRs=1.29-2.21),而只有人际暴力(HR=2.49)与 CD 的发病相关,且仅在女性中观察到。ODD 与发病无关。相反,ODD 和 CD 与后来暴露于人际暴力和其他/未披露事件的风险增加相关(HRs=1.45-1.75)。
通常在青春期开始的外化障碍,包括 SUD 和 CD,在有先前创伤的青少年中更有可能出现。相比之下,ODD 的发病与创伤暴露无关,但与以后发展中经历创伤的风险增加有关。CD 和人际暴力暴露表现出相互关联。这些发现对外化和与创伤相关的精神病理学的干预措施具有重要意义。