[Pharmacokinetic study of pefloxacin in 37 hospital patients under resuscitation].

Pharmacokinetics of pefloxacin were studied in thirty-seven intensive care patients. Fluorimetric assay was used for determining pefloxacin concentrations. Serum concentrations were usually far above threshold levels; however, wide variations across patients were evidenced, with no demonstrable relation to physiologic status. For this reason, pefloxacin assay is useful in high risk patients to avoid subconcentrations.