Efficacy and safety of pefloxacin in the treatment of severe infections in patients hospitalized in intensive care units.

Sixteen patients, 14 with an infection of the lower respiratory tract and two with cholangitis, were treated with pefloxacin 400 mg bid or tid. The original pathogens were eradicated in all but one patient. Pefloxacin therapy resulted in clinical cure in 11 patients, three patients were improved clinically and in two patients a clinical failure was observed. No adverse effects were noticed during or after pefloxacin administration.