Dellamonica P, Fournier J P, Garraffo R, Lapalus P, Bernard E, Chichmanian R M, Marty P, Le Fichoux Y
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):642-5.
The occurrence of hematologic and neurologic complications probably caused by an overdose of 5-FC has prompted us to study 5-FC pharmacokinetics in 10 patients under a 5-FC and amphotericin B. On the basis of our findings we have determined the optimal dosage that achieves desired concentrations. In 5 cases this dosages was found to differ from that suggested by the manufacturer. 5-FC concentrations were however higher than predicted levels as a result of the association with amphotericin B. A subsequent modification of dosage was needed in 10 patients. 5 undesirable side effects were recorded: thrombopenia (1 case), neutropenia (1 case), diarrhea (2 cases), and isolated rise in transaminases. In 4 patients with high 5-FC concentrations, chromatograms showed a peak possibly formed by 5-FU, suggesting that 5-FC may be converted into 5-FU.
血液学和神经学并发症的发生可能是由5-氟胞嘧啶（5-FC）过量所致，这促使我们对10例接受5-FC和两性霉素B治疗的患者进行5-FC药代动力学研究。根据我们的研究结果，我们确定了能达到所需浓度的最佳剂量。在5例患者中，发现该剂量与制造商建议的剂量不同。然而，由于与两性霉素B联合使用，5-FC浓度高于预测水平。10例患者随后需要调整剂量。记录到5例不良副作用：血小板减少（1例）、中性粒细胞减少（1例）、腹泻（2例）以及转氨酶单独升高。在4例5-FC浓度较高的患者中，色谱图显示有一个可能由5-氟尿嘧啶（5-FU）形成的峰，提示5-FC可能转化为5-FU。
