Pinheiro Ana Acacia Sá, Torrecilhas Ana Claudia, Souza Bruno Solano de Freitas, Cruz Fernanda Ferreira, Guedes Herbert Leonel de Matos, Ramos Tadeu Diniz, Lopes-Pacheco Miqueias, Caruso-Neves Celso, Rocco Patricia R M
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Rio de Janeiro, Brazil.
J Extracell Vesicles. 2024 Aug;13(8):e12496. doi: 10.1002/jev2.12496.
Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and host immune response modulation. Studies have shown that EVs play a role in parasitic disease development by interacting with parasites and communicating with other types of cells. This review highlights the most recent research on EVs and their role in several aspects of parasite-host interactions in five key parasitic diseases: Chagas disease, malaria, toxoplasmosis, leishmaniasis and helminthiases. We also discuss the potential use of EVs as diagnostic tools or treatment options for these infectious diseases.
寄生虫病对人类和动物健康有重大影响，是对公众的一大危害，并在全球范围内造成经济和健康损害。细胞外囊泡（EVs）长期以来一直被视为诊断和治疗工具，但现在也已知其与寄生虫病的自然史及宿主免疫反应调节有关。研究表明，细胞外囊泡通过与寄生虫相互作用以及与其他类型细胞进行通讯，在寄生虫病发展过程中发挥作用。本综述重点介绍了关于细胞外囊泡及其在恰加斯病、疟疾、弓形虫病、利什曼病和蠕虫病这五种主要寄生虫病的寄生虫-宿主相互作用的几个方面所起作用的最新研究。我们还讨论了细胞外囊泡作为这些传染病的诊断工具或治疗选择的潜在用途。
