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恶性疟中红细胞变形性降低与血管阻塞:一例致死病例说明

Decreased red cell deformability and vascular obstruction in falciparum malaria illustrated by a fatal case.

作者信息

Ahlqvist J

出版信息

Scand J Haematol. 1985 Nov;35(5):531-5. doi: 10.1111/j.1600-0609.1985.tb02824.x.

DOI:10.1111/j.1600-0609.1985.tb02824.x
PMID:3911374
Abstract

The autopsy findings in a case of falciparum malaria suggested that rheological mechanisms, above all decreased deformability of red cells, might have been the main cause of capillary obstruction. This mechanism had been assumed to be involved already in 1972, and red cells containing mature parasites have recently been shown to lack deformability. This may explain why severe cases have recovered after blood exchange.

摘要

一例恶性疟尸检结果表明,流变学机制,尤其是红细胞变形性降低,可能是毛细血管阻塞的主要原因。1972年就已推测该机制与之有关,最近发现含有成熟疟原虫的红细胞缺乏变形性。这或许可以解释为何严重病例在进行换血治疗后得以康复。

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