Rieckmann K H
Annu Rev Med. 1983;34:321-35. doi: 10.1146/annurev.me.34.020183.001541.
The spread of multidrug-resistant strains of Plasmodium falciparum poses an increasing threat to the effective treatment and prophylaxis of malaria. Recent advances in determining the drug sensitivity of malaria parasites should promote the more rational use of standard or alternative antimalarials in areas with emerging or well-established drug resistance. The use of currently available alternative drugs is usually associated with more problems than that of the standard, synthetic antimalarials. Safe and effective drugs, capable of being administered as a single-dose or short-course treatment, are urgently needed to control the adaptable malaria parasite.
恶性疟原虫多重耐药菌株的传播对疟疾的有效治疗和预防构成了日益严重的威胁。在确定疟原虫药物敏感性方面的最新进展应能促进在出现耐药性或耐药情况已很普遍的地区更合理地使用标准或替代抗疟药物。与标准的合成抗疟药物相比，目前使用替代药物通常会带来更多问题。迫切需要能够单剂量或短疗程给药的安全有效的药物来控制适应性强的疟原虫。
