Cai Qiuling, Yang Jing, Shen Huiling, Xu Wenlin
Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
Department of Oncology, The First Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
Am J Cancer Res. 2024 Jul 15;14(7):3259-3279. doi: 10.62347/XZRI9189. eCollection 2024.
The tumor microenvironment (TME) plays a critical role in high energy metabolism during tumorigenesis, progression and metastasis. Among them, adipocytes, as an important component of the TME, can transform into cancer-associated adipocytes (CAAs) through dedifferentiation via interactions with tumor cells. These CAAs provide nutrients, growth factors, cytokines and metabolites to the tumor and later transdifferentiate into other stromal cells at a later stage to alter tumor growth, metastasis and the drug response and ultimately influence the treatment and prognosis of ovarian cancer. This review outlines the physiological functions of CAAs and discusses the progress in the use of CAAs as therapeutic targets in ovarian cancer.
肿瘤微环境(TME)在肿瘤发生、进展和转移过程中的高能量代谢中起着关键作用。其中,脂肪细胞作为TME的重要组成部分,可通过与肿瘤细胞相互作用发生去分化,转变为癌症相关脂肪细胞(CAA)。这些CAA为肿瘤提供营养、生长因子、细胞因子和代谢产物,随后在后期转分化为其他基质细胞,从而改变肿瘤的生长、转移和药物反应,并最终影响卵巢癌的治疗和预后。本文综述了CAA的生理功能,并讨论了将CAA作为卵巢癌治疗靶点的研究进展。