Qian Minyue, Zhong Jia, Lu Zhongteng, Zhang Wenyuan, Weng Mengcao, Zhang Kai, Jin Yue
Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Anesthesiology and Intensive Care, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Int J Med Sci. 2024 Jul 16;21(10):1852-1865. doi: 10.7150/ijms.96851. eCollection 2024.
Triggering receptor expressed in myeloid cells 2 (TREM2), a transmembrane receptor, has garnered extensive research attention due to its pivotal role in the diagnosis and treatment of various diseases. Despite the abundance of studies on its function, there is a gap in comprehensive analysis and summarization of the current state of this research field. Articles and reviews related to TREM2 were retrieved from the Web of Science Core Collection (WOSCC) on October 1, 2023. A bibliometric analysis of TREM2 was conducted using CiteSpace, VOSviewer and Bibliometrix (R package). A total of 1,502 articles, spanning from 2001 to 2022, met the search criteria. The number of publications and citations has increased steadily over the years. The United States and China are the most active countries in TREM2 research, with the University of Washington as the leading research institution. The most influential journal in the field is Neurology of Aging. The predominant research areas include molecular, biology and immunology. Alzheimer's disease, microglia, variants, and inflammation are significant keywords. Emerging directions such as metabolism and tumor microenvironment have recently gained attention in numerous studies. The current study utilizes bibliometric analysis software and visual graphics to intuitively highlight TREM2-related hotspots, trends, and prospects in human disease. Such insights are valuable for scholars seeking a deeper understanding of TREM2-related research progress, enabling a focused approach to its application in human disease.
髓系细胞触发受体2（TREM2）是一种跨膜受体，因其在多种疾病的诊断和治疗中发挥关键作用而受到广泛的研究关注。尽管对其功能已有大量研究，但目前该研究领域的综合分析和总结仍存在空白。于2023年10月1日从科学网核心合集（WOSCC）检索了与TREM2相关的文章和综述。使用CiteSpace、VOSviewer和Bibliometrix（R包）对TREM2进行了文献计量分析。共有1502篇文章符合检索标准，时间跨度从2001年到2022年。这些年来，出版物数量和被引频次稳步增加。美国和中国是TREM2研究中最活跃的国家，华盛顿大学是领先的研究机构。该领域最具影响力的期刊是《衰老神经学》。主要研究领域包括分子生物学和免疫学。阿尔茨海默病、小胶质细胞、变体和炎症是重要的关键词。新陈代谢和肿瘤微环境等新兴方向最近在众多研究中受到关注。本研究利用文献计量分析软件和可视化图形直观地突出了TREM2在人类疾病中的相关热点、趋势和前景。这些见解对于寻求更深入了解TREM2相关研究进展的学者很有价值，有助于其有针对性地将TREM2应用于人类疾病。
