Aly Hebatalla M, Ibraheem Reham B, Mahmoud Reem M, Ismail Ahmed, Hussein Sarah M
Department of Public Health, Community, Occupational and Environmental Medicine, Suez Canal University, Ismailia, Egypt.
Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.
Indian J Occup Environ Med. 2024 Apr-Jun;28(2):143-147. doi: 10.4103/ijoem.ijoem_239_23. Epub 2024 Jun 28.
Polychlorinated biphenyls (PCBs) are persistent organic pollutants classified as endocrine disruptors related to prediabetes and diabetes. Polybrominated biphenyls are similar in structure to PCBs and are used as flame retardants. Due to the increased worldwide prevalence of diabetes, there is increased interest in understanding the role of environmental and occupational pollutants in its development. The study aims to assess the relation between PCBs and PBBs in the serum of electronic workers and glycated hemoglobin level as an early indicator of prediabetes and type 2 diabetes mellitus among occupationally exposed workers.
Blood samples were collected from 152 workers to assess PCBs (by GCMS), random blood sugar (RBS), and glycated hemoglobin (HbA1c). Participants were classified into two groups according to the presence or absence of PCBs in their serum and were compared for RBS and HbA1c levels.
Only two participants had detectable PCB derivate in their serum by GCMS, PCB 1 with methyl and benzole side chains. Regarding PBBs, 18 participants (12%) had detectable PBBs in their serum by GCMS. All participants had RBS and HbA1c levels within the normal range. No statistically significant difference was found between mean levels of RBS and HbA1c between participants with detected biphenyls and those without.
The banning of PCB use in industry and modern automated techniques have prevented exposure to PCBs among electronics workers. However, exposure to PBBs continues in electronic industries, but it has no association with diabetes or prediabetes.
多氯联苯（PCBs）是持久性有机污染物，被归类为与糖尿病前期和糖尿病相关的内分泌干扰物。多溴联苯在结构上与多氯联苯相似，用作阻燃剂。由于全球糖尿病患病率上升，人们对了解环境和职业污染物在其发展中的作用越来越感兴趣。本研究旨在评估电子行业工人血清中多氯联苯和多溴联苯与糖化血红蛋白水平之间的关系，糖化血红蛋白水平是职业暴露工人中糖尿病前期和2型糖尿病的早期指标。
采集152名工人的血样，以评估多氯联苯（通过气相色谱 - 质谱联用仪）、随机血糖（RBS）和糖化血红蛋白（HbA1c）。根据血清中是否存在多氯联苯将参与者分为两组，并比较其随机血糖和糖化血红蛋白水平。
通过气相色谱 - 质谱联用仪，血清中仅两名参与者检测到带有甲基和苯环侧链的多氯联苯衍生物PCB 1。关于多溴联苯，18名参与者（12%）血清中通过气相色谱 - 质谱联用仪检测到多溴联苯。所有参与者的随机血糖和糖化血红蛋白水平均在正常范围内。在检测到联苯的参与者和未检测到的参与者之间，随机血糖和糖化血红蛋白的平均水平未发现统计学上的显著差异。
工业中多氯联苯使用的禁令以及现代自动化技术已防止电子行业工人接触多氯联苯。然而，电子行业中多溴联苯的接触仍在继续，但它与糖尿病或糖尿病前期无关。
