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重度小儿镰状细胞视网膜病变病例报告：疾病表现、进展及治疗

Case Reports of Severe Paediatric Sickle Cell Retinopathy: Disease Manifestations, Progression and Treatments.

作者信息

Sourla Evdokia, Lip Peck Lin

机构信息

Birmingham and Midland Eye Centre, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, UK.

出版信息

Int Med Case Rep J. 2024 Aug 2;17:733-738. doi: 10.2147/IMCRJ.S467510. eCollection 2024.

DOI:10.2147/IMCRJ.S467510
PMID:39114266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303670/
Abstract

Severe sickle retinopathy is commonly known in adults but not in children, hence any related treatment for sickle retinopathy in children was not well described. We reported 2 paediatric sickle patients (aged 12 and 13) presented with severe sickle retinopathy and described details of their disease progression and treatments over 2-3 years, along with the challenges faced when managing this particular group of young age sickle cell patients. Our case reports also demonstrated the benefits of laser photocoagulation treatment to early sickle proliferative disease, and how complications from advanced severe retinopathy hindered effective treatments.

摘要

重度镰状视网膜病变在成人中较为常见，但在儿童中并不常见，因此儿童镰状视网膜病变的相关治疗方法尚无详细描述。我们报告了2例患有重度镰状视网膜病变的儿科镰状细胞病患者（年龄分别为12岁和13岁），描述了他们在2至3年中的疾病进展和治疗细节，以及管理这一特定年轻镰状细胞病患者群体时所面临的挑战。我们的病例报告还展示了激光光凝治疗对早期镰状细胞增殖性疾病的益处，以及晚期重度视网膜病变的并发症如何阻碍有效治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184a/11303670/d2010053c31e/IMCRJ-17-733-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184a/11303670/329c3dfe434f/IMCRJ-17-733-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184a/11303670/d2010053c31e/IMCRJ-17-733-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184a/11303670/329c3dfe434f/IMCRJ-17-733-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/184a/11303670/d2010053c31e/IMCRJ-17-733-g0002.jpg

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1
Case Reports of Severe Paediatric Sickle Cell Retinopathy: Disease Manifestations, Progression and Treatments.重度小儿镰状细胞视网膜病变病例报告：疾病表现、进展及治疗
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本文引用的文献

1
Prevalence and Onset of Pediatric Sickle Cell Retinopathy.儿童镰状细胞性视网膜病变的患病率和发病时间。
Ophthalmology. 2019 Jul;126(7):1000-1006. doi: 10.1016/j.ophtha.2019.02.023. Epub 2019 Mar 2.
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New Ways to Detect Pediatric Sickle Cell Retinopathy: A Comprehensive Review.检测小儿镰状细胞视网膜病变的新方法：全面综述
J Pediatr Hematol Oncol. 2017 Nov;39(8):618-625. doi: 10.1097/MPH.0000000000000919.
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Laser therapy for retinopathy in sickle cell disease.镰状细胞病视网膜病变的激光治疗
Cochrane Database Syst Rev. 2015 Oct 9;2015(10):CD010790. doi: 10.1002/14651858.CD010790.pub2.
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Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study.增殖性镰状细胞视网膜病变的发病率及自然病程：一项队列研究的观察结果
Ophthalmology. 2005 Nov;112(11):1869-75. doi: 10.1016/j.ophtha.2005.05.026. Epub 2005 Sep 19.
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When should children and young adults with sickle cell disease be referred for eye assessment?患有镰状细胞病的儿童和年轻人应在何时转诊进行眼部评估？
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Recent advances in the treatment of proliferative sickle cell retinopathy.增殖性镰状细胞视网膜病变治疗的最新进展
Curr Opin Ophthalmol. 1992 Jun;3(3):379-88. doi: 10.1097/00055735-199206000-00013.
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Relationship between peripheral vascular closure and proliferative retinopathy in sickle cell disease.镰状细胞病中外周血管闭塞与增殖性视网膜病变的关系。
Graefes Arch Clin Exp Ophthalmol. 1991;229(6):543-8. doi: 10.1007/BF00203319.