Chauhan Abhishek, Pathak Vinay Mohan, Yadav Monika, Chauhan Ritu, Babu Neelesh, Chowdhary Manish, Ranjan Anuj, Mathkor Darin Mansor, Haque Shafiul, Tuli Hardeep Singh, Ramniwas Seema, Yadav Vikas
Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida, Uttar Pradesh, India.
Parwatiya Shiksha Sabha (PASS), Haldwani, India.
Front Pharmacol. 2024 Jul 24;15:1405497. doi: 10.3389/fphar.2024.1405497. eCollection 2024.
Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioavailability and poor permeability, its clinical value is restricted. To deliver and protect the drug, liposomes and polymer micelles are two UA nanoformulations that can effectively increase medicine stability. The use of UA for treating cancers is safe and appropriate with low toxicity characteristics and a predictable pharmacokinetic profile. Although the bioavailability of UA is limited, its nanoformulations could emerge as an alternative to enhance its efficacy in treating GI cancers. Further optimization and validation in the clinical trials are necessary. The combination of molecular profiling with nanoparticle-based drug delivery technologies holds the potential for bringing UA to maximum efficacy, looking for good prospects with GI cancer treatment.
胃肠道恶性肿瘤是全球主要的健康问题之一。在本综述中，我们评估了熊果酸（UA）对胃肠道癌症可能的治疗意义。通过调节癌症发展中几个关键的信号通路，UA可具有抗炎、抗增殖和抗转移特性。然而，由于其口服生物利用度低且通透性差，其临床价值受到限制。为了递送和保护药物，脂质体和聚合物胶束是两种可有效提高药物稳定性的UA纳米制剂。使用UA治疗癌症是安全且合适的，具有低毒性特征和可预测的药代动力学特征。尽管UA的生物利用度有限，但其纳米制剂可能成为提高其治疗胃肠道癌症疗效的替代方法。在临床试验中进行进一步的优化和验证是必要的。分子谱分析与基于纳米颗粒的药物递送技术相结合，有望使UA发挥最大疗效，在胃肠道癌症治疗方面前景良好。
