Hashimoto Itaru, Komori Keisuke, Maezawa Yukio, Nagasawa Shinsuke, Kawabe Taiichi, Aoyama Toru, Hayashi Tsutomu, Yamada Takanobu, Sato Tsutomu, Ogata Takashi, Cho Haruhiko, Yoshikawa Takaki, Yukawa Norio, Rino Yasushi, Saito Aya, Oshima Takashi
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa 241-8515, Japan.
Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
Oncol Lett. 2024 Jul 25;28(4):458. doi: 10.3892/ol.2024.14591. eCollection 2024 Oct.
The association of computed tomography (CT)-derived skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) with postoperative prognosis in patients with gastric cancer (GC) remains unknown. Therefore, the present study aimed to assess the association between SMI and SMD with 5-year overall survival (OS) and recurrence-free survival (RFS) in patients with GC. SMI and SMD were measured preoperatively in patients who underwent gastrectomy. Patients were categorized into Groups 1 (high SMI and SMD), 2 (high SMI or SMD) and 3 (low SMI and SMD). OS and RFS rates were assessed using Kaplan-Meier analysis and the log-rank test. Among 459 patients, OS and RFS rates were significantly lower in the low-SMD group than in the high-SMD group (OS, 83.4% vs. 88.8%, respectively; P=0.04 and RFS, 80.5% vs. 87.2%, respectively; P=0.02). OS and RFS rates were also significantly lower in Group 3 than in Groups 2 and 1 (P=0.006). Multivariate analysis revealed that a low SMI and SMD (Group 3) was a significant independent prognostic factor for OS [hazard ratio (HR), 2.32; 95% confidence interval (CI), 1.17-4.59; P=0.016] and RFS (HR, 2.28; 95% CI, 1.19-4.37; P=0.013). In summary, low SMI and SMD values may be useful postoperative prognostic indicators for patients with GC.
计算机断层扫描（CT）得出的骨骼肌指数（SMI）和骨骼肌放射密度（SMD）与胃癌（GC）患者术后预后的关系尚不清楚。因此，本研究旨在评估GC患者中SMI和SMD与5年总生存期（OS）和无复发生存期（RFS）之间的关系。对接受胃切除术的患者术前测量SMI和SMD。患者被分为1组（高SMI和SMD）、2组（高SMI或SMD）和3组（低SMI和SMD）。使用Kaplan-Meier分析和对数秩检验评估OS和RFS率。在459例患者中，低SMD组的OS和RFS率显著低于高SMD组（OS分别为83.4%和88.8%；P=0.04；RFS分别为80.5%和87.2%；P=0.02）。3组的OS和RFS率也显著低于2组和1组（P=0.006）。多变量分析显示，低SMI和SMD（3组）是OS[风险比（HR），2.32；95%置信区间（CI），1.17-4.59；P=0.016]和RFS（HR，2.28；95%CI，1.19-4.37；P=0.013）的显著独立预后因素。总之，低SMI和SMD值可能是GC患者有用的术后预后指标。
