Zhang Mingcheng, Gong Liting, Chen Yan, Ding Ranran, Yang Zhaoxia
Center of Endoscopy, The Second Affiliated Hospital of Shandong First Medical University Tai'an, Shandong, China.
Department of Neurology, The Second Affiliated Hospital of Shandong First Medical University Tai'an, Shandong, China.
Am J Transl Res. 2024 Jul 15;16(7):3182-3190. doi: 10.62347/FEFU5237. eCollection 2024.
To understand the disease burden of esophageal cancer (EC) attributable to inadequate fruit intake in China and global from 1990 to 2019 stratified by age and sex.
Global Burden of Disease Study (GBD 2019) were pooled to calculate the number of deaths, standardized mortality rate, disability-adjusted life years (DALY) and DALY rate of EC attributed to low fruit intake in China and globally by age and sex from 1990 to 2019. The population attributable fractions (PAF) were applied to estimate the proportion of EC caused by low fruit intake. Joinpoint was used to estimate average annual percentage of change (AAPC) to reflect the time change trend of the EC burden attributable to inadequate fruit intake in China and globally.
In the Chinese population in 2019, the attributable DALY of EC in males was 356,000 person-years, while it was 80,600 person-years in females. The attributable standardized mortality and DALY rates for different age groups in China increased with age, peaking in the group aged 70 years and above. From 1990 to 2019 in China, the number of deaths, standardized mortality rates, DALY and standardized DALY rates of EC attributable to inadequate fruit intake showed a decreasing trend (AAPCs: -1.62%, -4.54%, -2.10% and -4.88%, respectively), with statistical significance (<0.001).
The overall burden of EC attributed to inadequate fruit intake in China has demonstrated a downward trend. However, due to the aging population, the disease burden in China remains higher than the global average. Hence, prevention and health education efforts should focus on the population with low fruit intake.
了解1990年至2019年按年龄和性别分层的中国及全球因水果摄入量不足导致的食管癌疾病负担。
汇总全球疾病负担研究（GBD 2019）的数据，计算1990年至2019年中国及全球按年龄和性别划分的因水果摄入量低导致的食管癌死亡人数、标准化死亡率、伤残调整生命年（DALY）和DALY率。应用人群归因分数（PAF）来估计水果摄入量低导致的食管癌比例。采用Joinpoint软件估计平均年度变化百分比（AAPC），以反映中国及全球因水果摄入量不足导致的食管癌负担的时间变化趋势。
2019年中国人群中，男性因食管癌导致的归因DALY为35.6万人年，女性为8.06万人年。中国不同年龄组的归因标准化死亡率和DALY率随年龄增长而增加，在70岁及以上年龄组达到峰值。1990年至2019年期间，中国因水果摄入量不足导致的食管癌死亡人数、标准化死亡率、DALY和标准化DALY率均呈下降趋势（AAPC分别为-1.62%、-4.54%、-2.10%和-4.88%），差异具有统计学意义（<0.001）。
中国因水果摄入量不足导致的食管癌总体负担呈下降趋势。然而，由于人口老龄化，中国的疾病负担仍高于全球平均水平。因此，预防和健康教育工作应重点关注水果摄入量低的人群。
