Fang Yueying, Wang Jian, Nie Dongliang, Tang Yihua
Department of Neurology, The First People's Hospital of Fuyang District Hangzhou 311400, Zhejiang, China.
Am J Transl Res. 2024 Jul 15;16(7):2852-2863. doi: 10.62347/JTRH2408. eCollection 2024.
To evaluate the efficacy of exercise interventions combined with Selegiline in ameliorating freezing of gait (FOG) in Parkinson's disease (PD) patients.
A total of 60 PD patients with FOG treated in the First People's Hospital of Fuyang District from January 2020 to January 2023 were retrospectively collected and analyzed. Patients were divided into a control group (n = 28, treated with Selegiline alone) and an observation group (n = 32, treated with Selegiline and exercise interventions). Gait parameters, FOG indices, motor and balance functions, Berg Balance, psychological status, and quality of life were compared between the groups pre- and post-treatment.
After treatment, the observation group exhibited longer step length, higher step speed, and lower step frequency (P = 0.000, 0.003, 0.001, respectively), with enhanced balance as indicated by lower Timed Up and Go Test and higher Berg Balance Scale scores than the control group (P = 0.000, 0.000, respectively). The Beck Depression Inventory and Beck Anxiety Inventory scores were notably lower in the observation group than those in the control group (P = 0.000, 0.004, respectively). Additionally, the observation group showed better quality of life across several dimensions of the Parkinson's Disease Quality of Life Questionnaire, including mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort (P = 0.000, 0.000, 0.000, 0.000, 0.017, 0.000, 0.000, 0.000, respectively) than the control group.
The combination of exercise interventions and Selegiline effectively rectifies the gait parameters, enhances the balance function, alleviates psychological distress, and improves the overall quality of life in PD patients experiencing FOG.
评估运动干预联合司来吉兰改善帕金森病（PD）患者冻结步态（FOG）的疗效。
回顾性收集并分析2020年1月至2023年1月在富阳区第一人民医院治疗的60例伴有FOG的PD患者。将患者分为对照组（n = 28，仅接受司来吉兰治疗）和观察组（n = 32，接受司来吉兰和运动干预治疗）。比较两组治疗前后的步态参数、FOG指数、运动和平衡功能、伯格平衡量表、心理状态及生活质量。
治疗后，观察组步长更长、步速更快、步频更低（P分别为0.000、0.003、0.001），起立行走测试得分更低、伯格平衡量表得分更高，表明平衡功能增强，优于对照组（P分别为0.000、0.000）。观察组贝克抑郁量表和贝克焦虑量表得分显著低于对照组（P分别为0.000、0.004）。此外，在帕金森病生活质量问卷的多个维度上，观察组的生活质量均优于对照组，包括运动、日常生活活动、情绪健康、耻辱感、社会支持、认知、沟通和身体不适（P分别为0.000、0.000、0.000、0.000、0.017、0.000、0.000、0.000）。
运动干预与司来吉兰联合使用可有效纠正PD伴FOG患者的步态参数，增强平衡功能，减轻心理困扰，提高整体生活质量。
