• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

复发性呼吸道乳头状瘤病的游离DNA分析：一例报告

Cell-free DNA analysis for recurrent respiratory papillomatosis: A case report.

作者信息

Yamada Satoshi, Kano Kotaro, Ishikawa Ryuji, Imai Atsushi, Mochizuki Daiki, Morita Kotaro, Takeuchi Kazutaka, Takizawa Yoshinori, Kawasaki Hideya, Misawa Kiyoshi

机构信息

Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan.

Department of Otolaryngology Yaizu City Hospital Yaizu Japan.

出版信息

Clin Case Rep. 2024 Aug 6;12(8):e9268. doi: 10.1002/ccr3.9268. eCollection 2024 Aug.

DOI:10.1002/ccr3.9268
PMID:39114832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303445/
Abstract

A 35-year-old male presented with recurrent respiratory papillomatosis. Human papillomavirus type 11 was detected from all sites of tumor tissue DNA by PCR. The pre-surgery cell-free DNA (cfDNA) viral load (3.33 × 10 copies/ng DNA) fell below the post-surgical detection limits on achieving remission, suggesting cfDNA's potential as a biomarker.

摘要

一名35岁男性患有复发性呼吸道乳头瘤病。通过聚合酶链反应（PCR）在肿瘤组织DNA的所有部位均检测到11型人乳头瘤病毒。术前游离DNA（cfDNA）病毒载量（3.33×10拷贝/ng DNA）在实现缓解时降至术后检测限以下，表明cfDNA有作为生物标志物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/eaec6dc4d13c/CCR3-12-e9268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/7ec0246f939f/CCR3-12-e9268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/dfc75a9826bb/CCR3-12-e9268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/a66318277f30/CCR3-12-e9268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/2dc557141e43/CCR3-12-e9268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/eaec6dc4d13c/CCR3-12-e9268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/7ec0246f939f/CCR3-12-e9268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/dfc75a9826bb/CCR3-12-e9268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/a66318277f30/CCR3-12-e9268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/2dc557141e43/CCR3-12-e9268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477f/11303445/eaec6dc4d13c/CCR3-12-e9268-g001.jpg

相似文献

1
Cell-free DNA analysis for recurrent respiratory papillomatosis: A case report.复发性呼吸道乳头状瘤病的游离DNA分析：一例报告
Clin Case Rep. 2024 Aug 6;12(8):e9268. doi: 10.1002/ccr3.9268. eCollection 2024 Aug.
2
Human papillomavirus, viral load and proliferation rate in recurrent respiratory papillomatosis in response to alpha interferon treatment.复发性呼吸道乳头状瘤病中人类乳头瘤病毒、病毒载量及增殖率对α干扰素治疗的反应
J Gen Virol. 2005 Jun;86(Pt 6):1695-1702. doi: 10.1099/vir.0.80849-0.
3
Viral load and mRNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis.复发性呼吸道乳头状瘤病患者中6型人乳头瘤病毒的病毒载量及mRNA表达
Laryngoscope. 2016 Jan;126(1):122-7. doi: 10.1002/lary.25357. Epub 2015 May 22.
4
A pilot study on salivary HPV DNA detection to monitor active disease from patients with recurrent respiratory papillomatosis.一项关于唾液 HPV DNA 检测以监测复发性呼吸道乳头状瘤病患者活动性疾病的初步研究。
Am J Otolaryngol. 2024 Mar-Apr;45(2):104157. doi: 10.1016/j.amjoto.2023.104157. Epub 2023 Dec 5.
5
Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis.复发性呼吸道乳头瘤病患儿人乳头瘤病毒6型和11型病毒载量及抗体反应的纵向测量
Arch Otolaryngol Head Neck Surg. 2006 Jul;132(7):711-5. doi: 10.1001/archotol.132.7.711.
6
Juvenile respiratory papillomatosis: risk factors for severity.儿童呼吸道乳头瘤病：严重程度的危险因素。
J Med Virol. 2013 Aug;85(8):1447-58. doi: 10.1002/jmv.23615.
7
Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate: a case report.鼻腔内翻性乳头状瘤与复发性呼吸道乳头状瘤的新型同步累及，鼻中隔和中鼻甲分离出确诊的人乳头瘤病毒：病例报告
J Med Case Rep. 2019 Jul 15;13(1):215. doi: 10.1186/s13256-019-2153-1.
8
A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy.一例由复发性呼吸道乳头状瘤病恶变引起的原发性气管鳞状细胞癌，对同步放化疗完全缓解。
SAGE Open Med Case Rep. 2021 Oct 21;9:2050313X211054623. doi: 10.1177/2050313X211054623. eCollection 2021.
9
Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary involvement: emerging common pattern of clinical features and human papillomavirus serotype association.复发性呼吸道乳头状瘤病伴肺部受累时发生的鳞状细胞癌：临床特征和人乳头瘤病毒血清型关联的新出现的常见模式
Mod Pathol. 2000 Aug;13(8):914-8. doi: 10.1038/modpathol.3880164.
10
Transcriptomic Landscape of Gene Expression Profiles and Pathways in Juvenile-Onset Recurrent Respiratory Papillomatosis Tumor Tissues and Human Papillomavirus 6 and 11 E6- and E7-Overexpressing Head and Neck Squamous Cell Carcinoma Cell Lines.转录组水平下基因表达谱和通路在青少年复发性呼吸道乳头瘤病肿瘤组织及人乳头瘤病毒 6 型和 11 型 E6 和 E7 过表达的头颈部鳞状细胞癌细胞系中的特征。
J Virol. 2022 Jan 26;96(2):e0134221. doi: 10.1128/JVI.01342-21. Epub 2021 Oct 20.

本文引用的文献

1
Applications and challenges of neural networks in otolaryngology (Review).神经网络在耳鼻喉科学中的应用与挑战（综述）
Biomed Rep. 2024 Apr 19;20(6):92. doi: 10.3892/br.2024.1781. eCollection 2024 Jun.
2
Blood and saliva-derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus-associated head and neck cancer.血液和唾液来源的 ctDNA 是治疗后残留疾病的标志物，与 HPV 相关的头颈部癌症的复发相关。
Cancer Med. 2023 Aug;12(15):15777-15787. doi: 10.1002/cam4.6191. Epub 2023 Aug 1.
3
Predictive impact of human papillomavirus circulating tumor DNA in treatment response monitoring of HPV-associated cancers; a meta-analysis on recurrent event endpoints.
循环肿瘤 HPV DNA 对 HPV 相关癌症治疗反应监测的预测影响：针对复发性事件终点的荟萃分析。
Cancer Med. 2023 Sep;12(17):17592-17602. doi: 10.1002/cam4.6377. Epub 2023 Jul 26.
4
Human Papillomavirus Infection and Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.人乳头瘤病毒感染与鼻窦内翻性乳头状瘤和鳞状细胞癌中的20号外显子插入
J Pers Med. 2023 Apr 11;13(4):657. doi: 10.3390/jpm13040657.
5
Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis.人乳头瘤病毒颗粒产生与复发性呼吸道乳头状瘤病严重程度的关联。
Sci Rep. 2023 Apr 6;13(1):5514. doi: 10.1038/s41598-023-32486-8.
6
Long-Term Follow-up of Parenteral Bevacizumab In Patients with Recurrent Respiratory Papillomatosis.肠外贝伐珠单抗治疗复发性呼吸道乳头瘤病患者的长期随访。
Laryngoscope. 2023 Oct;133(10):2725-2733. doi: 10.1002/lary.30617. Epub 2023 Feb 23.
7
Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer.游离 DNA 中 HPV 拷贝数的纵向测量与 HPV 阳性口咽癌患者的结局相关。
Eur J Surg Oncol. 2022 Jun;48(6):1224-1234. doi: 10.1016/j.ejso.2022.03.232. Epub 2022 Apr 6.
8
Development of Antibodies against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma.针对 HPV-6 和 HPV-11 的抗体的开发，用于喉部乳头瘤的研究。
Viruses. 2021 Oct 7;13(10):2024. doi: 10.3390/v13102024.
9
Performance of oral HPV DNA, oral HPV mRNA and circulating tumor HPV DNA in the detection of HPV-related oropharyngeal cancer and cancer of unknown primary.口腔人乳头瘤病毒（HPV）DNA、口腔HPV信使核糖核酸（mRNA）及循环肿瘤HPV DNA在检测HPV相关口咽癌及原发灶不明癌症中的性能
Int J Cancer. 2022 Jan 1;150(1):174-186. doi: 10.1002/ijc.33798. Epub 2021 Sep 20.
10
Liquid biopsy enters the clinic - implementation issues and future challenges.液体活检进入临床——实施问题与未来挑战。
Nat Rev Clin Oncol. 2021 May;18(5):297-312. doi: 10.1038/s41571-020-00457-x. Epub 2021 Jan 20.