复发性呼吸道乳头状瘤病的游离DNA分析：一例报告
Cell-free DNA analysis for recurrent respiratory papillomatosis: A case report.
作者信息
Yamada Satoshi, Kano Kotaro, Ishikawa Ryuji, Imai Atsushi, Mochizuki Daiki, Morita Kotaro, Takeuchi Kazutaka, Takizawa Yoshinori, Kawasaki Hideya, Misawa Kiyoshi
机构信息
Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan.
Department of Otolaryngology Yaizu City Hospital Yaizu Japan.
出版信息
Clin Case Rep. 2024 Aug 6;12(8):e9268. doi: 10.1002/ccr3.9268. eCollection 2024 Aug.
A 35-year-old male presented with recurrent respiratory papillomatosis. Human papillomavirus type 11 was detected from all sites of tumor tissue DNA by PCR. The pre-surgery cell-free DNA (cfDNA) viral load (3.33 × 10 copies/ng DNA) fell below the post-surgical detection limits on achieving remission, suggesting cfDNA's potential as a biomarker.
一名35岁男性患有复发性呼吸道乳头瘤病。通过聚合酶链反应（PCR）在肿瘤组织DNA的所有部位均检测到11型人乳头瘤病毒。术前游离DNA（cfDNA）病毒载量（3.33×10拷贝/ng DNA）在实现缓解时降至术后检测限以下，表明cfDNA有作为生物标志物的潜力。
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