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Potential epigenetic markers of clinical diagnostics/therapeutic targets in preeclampsia.子痫前期临床诊断/治疗靶点的潜在表观遗传标志物。
Epigenomics. 2024;16(15-16):1057-1060. doi: 10.1080/17501911.2024.2383558. Epub 2024 Aug 8.
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DNA methylation profiles in preeclampsia and healthy control placentas.子痫前期和健康对照胎盘的DNA甲基化图谱。
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An Exploratory Study of Epigenetic Age in Preeclamptic and Normotensive Pregnancy Reveals Differences by Self-Reported Race but Not Pregnancy Outcome.一项关于子痫前期和正常妊娠中表观遗传年龄的探索性研究表明，种族不同，但妊娠结局相同。
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本文引用的文献

1
Cell-free DNA methylome analysis for early preeclampsia prediction.用于早期子痫前期预测的游离DNA甲基化组分析
Nat Med. 2023 Sep;29(9):2206-2215. doi: 10.1038/s41591-023-02510-5. Epub 2023 Aug 28.
2
Low dose acetyl salicylic acid (LDA) mediates epigenetic changes in preeclampsia placental mesenchymal stem cells similar to cells from healthy pregnancy.低剂量乙酰水杨酸（LDA）可介导子痫前期胎盘间充质干细胞发生表观遗传学改变，类似于健康妊娠细胞。
Placenta. 2023 Jun;137:49-58. doi: 10.1016/j.placenta.2023.04.010. Epub 2023 Apr 13.
3
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review.早孕期循环 microRNAs 与妊娠并发症：系统评价。
Epigenetics. 2023 Dec;18(1):2152615. doi: 10.1080/15592294.2022.2152615. Epub 2022 Dec 12.
4
Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia.循环中组织金属蛋白酶抑制剂 3 的水平升高，该蛋白对血管生成具有抑制作用，在子痫前期中增加。
Int J Gynaecol Obstet. 2023 May;161(2):544-551. doi: 10.1002/ijgo.14552. Epub 2022 Nov 21.
5
The exosome: a review of current therapeutic roles and capabilities in human reproduction.外泌体：在人类生殖中的治疗作用和能力的综述。
Drug Deliv Transl Res. 2023 Feb;13(2):473-502. doi: 10.1007/s13346-022-01225-3. Epub 2022 Aug 18.
6
Clinical tools and biomarkers to predict preeclampsia.预测子痫前期的临床工具和生物标志物。
EBioMedicine. 2022 Jan;75:103780. doi: 10.1016/j.ebiom.2021.103780. Epub 2021 Dec 23.
7
Comprehensive analyses of DNA methylation of the TIMP3 promoter in placentas from early-onset and late-onset preeclampsia.全面分析早发型和晚发型子痫前期胎盘组织中 TIMP3 启动子的 DNA 甲基化。
Placenta. 2022 Jan;117:118-121. doi: 10.1016/j.placenta.2021.12.003. Epub 2021 Dec 4.
8
Cell-free DNA as a potential biomarker for preeclampsia.游离DNA作为子痫前期的潜在生物标志物。
Expert Rev Mol Diagn. 2021 Dec;21(12):1253-1256. doi: 10.1080/14737159.2021.1997593. Epub 2021 Oct 29.
9
Circulating MicroRNAs in the Second Trimester From Pregnant Women Who Subsequently Developed Preeclampsia: Potential Candidates as Predictive Biomarkers and Pathway Analysis for Target Genes of miR-204-5p.孕中期循环微RNA与子痫前期的关系：miR-204-5p靶基因作为预测生物标志物的潜在候选物及通路分析
Front Physiol. 2021 Sep 22;12:678184. doi: 10.3389/fphys.2021.678184. eCollection 2021.
10
Pre-eclampsia.子痫前期。
Lancet. 2021 Jul 24;398(10297):341-354. doi: 10.1016/S0140-6736(20)32335-7. Epub 2021 May 27.

Potential epigenetic markers of clinical diagnostics/therapeutic targets in preeclampsia.

作者信息

de Oliveira Cruz Juliana, Luizon Marcelo Rizzatti

机构信息

Department of Biological Sciences, Santa Cruz State University, Ilhéus, Bahia, 45662-900, Brazil.

Graduate Program of Genetics, Institute of Biological Sciences, Federal University of Minas Gerais; Belo Horizonte, Minas Gerais, 31270-901, Brazil.

出版信息

Epigenomics. 2024;16(15-16):1057-1060. doi: 10.1080/17501911.2024.2383558. Epub 2024 Aug 8.

DOI:10.1080/17501911.2024.2383558
PMID:39115080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11418293/
Abstract
摘要