Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
New York Medical College School of Medicine, Valhalla, NY, USA.
Epigenetics. 2023 Dec;18(1):2152615. doi: 10.1080/15592294.2022.2152615. Epub 2022 Dec 12.
Most pregnancy complications originate with early placentation. MicroRNAs (miRNAs) may play an important role in placentation and function as biomarkers of future pregnancy complications. We summarized from the literature all first trimester circulating miRNAs associated with pregnancy complications of placental origin and further identified the miRNAs which have the most evidence as potential early biomarkers for pregnancy complications. We conducted a systematic review following PRISMA reporting guidelines (PROSPERO CRD42020183421). We identified all first trimester serum or plasma miRNAs associated with a pregnancy complication of placental origin (preeclampsia, intrauterine growth restriction (IUGR), gestational hypertension, preterm delivery) and the number of times those miRNAs were identified, as a measure of replication. Twenty-one studies examined 118 unique miRNAs, and 87 were associated with at least one pregnancy complication; preeclampsia was the most common. Seven miRNAs were significantly associated with a pregnancy complication in at least two studies: miR-125b, miR-518b, miR-628-3p, miR-365a-3p, miR-520h, miR-374a-5p, miR-191-5p. Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR-191-5p with preterm birth and preeclampsia. Our systematic review suggests seven miRNAs as potential biomarkers of pregnancy complications. These complications are thought to originate with early placental defects and these miRNAs may also be biomarkers of placental pathology. First-trimester biomarkers of pregnancy complications can facilitate early detection and interventions.
大多数妊娠并发症源于早期胎盘形成。微小 RNA（miRNA）可能在胎盘形成中发挥重要作用，并作为未来妊娠并发症的生物标志物。我们从文献中总结了所有与胎盘源性妊娠并发症相关的第一孕期循环 miRNA，并进一步确定了作为妊娠并发症潜在早期生物标志物最有证据的 miRNA。我们按照 PRISMA 报告指南（PROSPERO CRD42020183421）进行了系统评价。我们确定了所有与胎盘源性妊娠并发症（子痫前期、宫内生长受限（IUGR）、妊娠期高血压、早产）相关的第一孕期血清或血浆 miRNA，以及这些 miRNA 被识别的次数，作为重复的衡量标准。21 项研究共检测了 118 个独特的 miRNA，其中 87 个与至少一种妊娠并发症相关；子痫前期最常见。有 7 个 miRNA 在至少两项研究中与妊娠并发症显著相关：miR-125b、miR-518b、miR-628-3p、miR-365a-3p、miR-520h、miR-374a-5p、miR-191-5p。少数 miRNA 与多种妊娠并发症相关：miR-518b 和 miR-520h 与子痫前期和妊娠期高血压相关，miR-374a-5p 和 miR-191-5p 与早产和子痫前期相关。我们的系统评价表明，有 7 个 miRNA 可能是妊娠并发症的生物标志物。这些并发症被认为源于早期胎盘缺陷，这些 miRNA 也可能是胎盘病理的生物标志物。妊娠并发症的第一孕期生物标志物可以促进早期发现和干预。
