Lu Yifan, Zhai Shuqi, Liu Qinqin, Dai Congcong, Liu Shejuan, Shang Yanqing, Chen Chaoran
Institute of Nursing and Health, College of Nursing and Health, Henan University, Kaifeng, Henan, China.
College of Clinical Medicine, Henan University, Kaifeng, Henan, China.
Ren Fail. 2024 Dec;46(2):2382314. doi: 10.1080/0886022X.2024.2382314. Epub 2024 Aug 8.
Patients receiving renal dialysis often experience a wide range of symptoms. These symptoms contribute to a significant symptom burden that significantly affects patients' quality of life and serves as a significant predictor of healthcare resource utilization and patient prognosis. It is necessary to synthesize existing evidence to draw reliable conclusions to deepen the understanding of symptom burden.
A systematic review and meta-analysis were conducted to identify the relevant factors of symptom burden in patients receiving renal dialysis.
The systematic review and meta-analysis was conducted by searching nine databases for studies reporting the correlates between symptom burden and demographic variables, disease factors, and psychosocial factors from inception to 24 June 2024. After two researchers independently conducted literature search, data extraction, and quality evaluation, meta-analysis was conducted using R Language and Stata 15.1 Software. This study has been registered in the PROSPERO.
Sixty-two studies were included in this review. Results showed that the symptom burden of renal dialysis patients was positively correlated with age, gender, working status, medical cost, dialysis age, quality of sleep, nutritional status, comorbidities, depression, anxiety, disease uncertain, avoidance coping and resignation coping, and negatively correlated with marital status, income, serum sodium, quality of life, social support, subjective well-being, and self-management ability.
Our findings reveal that many factors, including demographic, disease-related, and psychosocial variables, affect symptom burden. The results can supply information for health promotion and relief symptom burden for patients receiving renal dialysis. CRD42024507577.
接受肾脏透析的患者常经历多种症状。这些症状导致了显著的症状负担，严重影响患者的生活质量，并成为医疗资源利用和患者预后的重要预测指标。有必要综合现有证据得出可靠结论，以加深对症状负担的理解。
进行系统评价和荟萃分析，以确定接受肾脏透析患者症状负担的相关因素。
通过检索九个数据库进行系统评价和荟萃分析，纳入从数据库建库至2024年6月24日报告症状负担与人口统计学变量、疾病因素和心理社会因素之间相关性的研究。两名研究人员独立进行文献检索、数据提取和质量评估后，使用R语言和Stata 15.1软件进行荟萃分析。本研究已在国际前瞻性系统评价注册库（PROSPERO）注册。
本评价纳入了62项研究。结果显示，肾脏透析患者的症状负担与年龄、性别、工作状态、医疗费用、透析年限、睡眠质量、营养状况、合并症、抑郁、焦虑、疾病不确定性、回避应对和屈服应对呈正相关，与婚姻状况、收入、血清钠、生活质量、社会支持、主观幸福感和自我管理能力呈负相关。
我们的研究结果表明，包括人口统计学、疾病相关和心理社会变量在内的许多因素都会影响症状负担。这些结果可为接受肾脏透析的患者促进健康和减轻症状负担提供信息。国际前瞻性系统评价注册库编号：CRD42024507577。
