Department of Ophthalmology, Macuria- Die Makulaexperten Augenpraxis, Meckenbeuren, Germany.
Department of Ophthalmology, Training and Research Hospital, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Ocul Immunol Inflamm. 2024 Dec;32(10):2405-2410. doi: 10.1080/09273948.2024.2382928. Epub 2024 Aug 8.
To compare the effect of different doses of vancomycin on a rabbit model of MRSA keratitis.
Twenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was applied to 24 left eyes of 24 New Zealand rabbits. Twenty-four hours after MRSA inoculation; 0.5 mg/0.1 mL, 1 mg/0.1 mL, and 2 mg/0.1 mL and balanced salt solution were administered to 6 rabbits in 4 groups, respectively.
The effect of different doses of vancomycin on reducing bacterial load was found to be statistically significant when each was compared to the control group ( = 0.006). When comparing the dosages with each other, no superiority was shown ( = 0.297, = 0.749, = 0.262 respectively). There was a significant increase in the posttreatment total clinical score in the control and 2 mg/0.1 mL groups compared to the pretreatment score ( = 0.001, = 0.001 respectively).
It is emphasized that necessary treatment can be achieved by administering less antibiotic (0.5 mg/0.1 mL) to the corneal intrastromal area.
比较不同剂量万古霉素对兔耐甲氧西林金黄色葡萄球菌（MRSA）角膜炎模型的疗效。
本研究纳入 24 只新西兰白兔的 24 只眼。将 MRSA 接种于 24 只新西兰白兔的 24 只左眼。在接种 MRSA 后 24 小时，将 0.5mg/0.1mL、1mg/0.1mL 和 2mg/0.1mL 以及平衡盐溶液分别注入 4 组中的 6 只兔子的左眼。
与对照组相比，不同剂量万古霉素对降低细菌负荷的效果具有统计学意义（=0.006）。当相互比较剂量时，没有显示出优越性（=0.297、=0.749、=0.262）。与治疗前相比，对照组和 2mg/0.1mL 组治疗后的总临床评分明显升高（=0.001、=0.001）。
强调可以通过向角膜基质内区域给予较少的抗生素（0.5mg/0.1mL）来实现必要的治疗。
