Department of Obstetrics and Gynecology, University of Washington, NE Pacific ST, Box 356460, Seattle, WA, 98195-6460, USA.
Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA, USA.
Curr Oncol Rep. 2024 Nov;26(11):1355-1366. doi: 10.1007/s11912-024-01587-6. Epub 2024 Aug 8.
To describe current and future strategies to reduce the burden of ovarian cancer through prevention.
Current strategies in genetic testing are missing a substantial number of individuals at risk, representing a missed opportunity for ovarian cancer prevention. Past efforts at screening and early detection have thus far failed to improve ovarian cancer mortality, and novel techniques are needed. Surgical prevention is highly effective, but surgical menopause from oophorectomy has significant side effects. Novel surgical strategies aimed at reducing risk while minimizing these harms are currently being studied. To maximize ovarian cancer prevention, a multi-pronged approach is needed. We propose that more inclusive and accurate genetic testing to identify more individuals at risk, novel molecular screening and early detection, surgical prevention that maximizes quality of life while reducing risk, and broader adoption of targeted and opportunistic salpingectomy will together reduce the burden of ovarian cancer.
描述通过预防来降低卵巢癌负担的当前和未来策略。
目前的遗传检测策略遗漏了相当数量的高危人群，这是卵巢癌预防的一个错失的机会。过去的筛查和早期检测工作都未能降低卵巢癌死亡率，因此需要新的技术。手术预防非常有效，但卵巢切除术引起的手术绝经有显著的副作用。目前正在研究旨在降低风险的同时最大限度减少这些危害的新手术策略。为了最大限度地预防卵巢癌，需要采取多管齐下的方法。我们建议更具包容性和准确性的遗传检测以识别更多的高危人群，新型的分子筛查和早期检测，最大限度地提高生活质量同时降低风险的手术预防，以及更广泛地采用靶向和机会性输卵管切除术，这些策略将共同降低卵巢癌的负担。
