Conventional ultrasonography enabled with augmented reality needle guidance for percutaneous kidney access: an innovative methodologies randomized controlled trial.

IMPORTANCE

Successful needle puncture of the renal collecting system is a critical but difficult procedure in percutaneous nephrolithotomy (PCNL). Although fluoroscopy and ultrasound are the standard imaging techniques to guide puncture during PCNL, both have known limitations.

OBJECTIVE

To assess the feasibility and safety of a new navigation system for needle puncture in ultrasound-guided PCNL.

DESIGN

This study employed a single-center randomized controlled trial (RCT) design to assess the feasibility and safety of a new navigation system for needle puncture in ultrasound-guided PCNL. Conducted between May 2021 and November 2021, the trial utilized computer-generated random numbers for participant allocation to control for selection bias.

SETTING

The trial was executed at Department of Urology, Peking University First Hospital in Beijing, China, which serves as an academic medical center.

PARTICIPANTS

All patients who met the inclusion criteria were randomly divided into two groups, with 29 patients in each group. One group underwent PCNL procedures using the new navigation system, while the control group underwent standard ultrasound-guided PCNL procedures. Included patients had renal pelvis or caliceal calculi larger than 2.0 cm in diameter or had multiple or staghorn stones. The puncture procedure was performed with the support of real-time ultrasound imaging and visual guidance displayed on the screen.

MAIN OUTCOMES AND MEASURES

The primary outcome was system feasibility and puncture success rate. Secondary outcomes included puncture time, total surgical time, number of attempts, postprocedure complications, and 1-year and 3-year stone recurrence rates. Stone clearance was defined by postoperative CT. Descriptive statistics summarized patient demographics, stone size, and location. Independent samples t -tests analyzed puncture time and total surgical time. χ2 or Fisher's exact tests compared stone clearance, complications, socioeconomic status, renal hydronephrosis, stone location, race, and medical history. Linear regression examined the correlation between BMI and puncture time. Significance was set at P <0.05.

RESULTS

For all 58 patients undergoing PCNL, needle punctures of the renal collecting system were completed with a success rate of 100%. The average time from planning the puncture protocol to successful puncture was significantly shorter in the AcuSee guidance system group (3.12 min, range 0.2-6.88 min) compared to the standard ultrasound-guided group (7.58 min, range 5.41-10.68 min), representing a reduction of ~59%. The total surgical time was also shorter in the AcuSee group for patients with no and mild hydronephrosis ( P <0.05). Complication rates were lower in the AcuSee group, with no major complications observed. However, three patients in the standard ultrasound-guided group have adverse effects after the PCNL procedure. The 1-year stone recurrence rate was significantly lower in the AcuSee group (3.4%) compared to the standard group (24.1%), and the 3-year recurrence rate was also lower (6.9% vs. 41.4%). Patient-specific factors such as BMI, renal morphology, and prior surgical history did not significantly affect the performance of the AcuSee system.

CONCLUSIONS AND RELEVANCE

The authors report the first clinical application of a new navigation system for needle puncture in ultrasound-guided PCNL. It has been demonstrated that it is feasible and safe compared to the standard ultrasound-guided group in percutaneous renal puncture. This technology provides intuitive and easy-to-use visual guidance, which may facilitate safe, accurate, and fast needle puncture of the kidney.