Doerr W
Zentralbl Allg Pathol. 1985;130(4):299-306.
In a historical view the development of the concept of inflammation and the assessment of its importance are considered in the light of the situation in the field of pathologic anatomy in the last century dominated as it was by the work of Cruveilhier, Rokitansky and Virchow. It is to Cohnheim that we owe the realization that inflammatory cells originate in the circulation. He attributed this to an alteration of the vessel wall. Years before the tuberculosis bacillus was discovered, Cohnheim recognized the disease as a single entity. He also distinguished "tumours" of infectious origin from true neoplasms. Observations made by Cohnheim continue to form part of the contemporary body of knowledge, for example the rejection of an acellular origin for inflammatory cells. Cohnheim's work provides the basis for current notions of allergy, granuloma formation and the pathologic changes associated with tuberculosis. Similarly our pathobiochemical views of inflammation are ultimately based on the appreciation of changes in microcirculation and capillary permeability.
从历史角度来看，炎症概念的发展及其重要性的评估是根据上世纪病理解剖学领域的情况来考量的，当时该领域由克鲁维耶、罗基坦斯基和魏尔啸的工作主导。我们要归功于科恩海姆认识到炎症细胞起源于血液循环。他将此归因于血管壁的改变。在结核杆菌被发现的多年前，科恩海姆就将这种疾病视为一个单一实体。他还区分了感染性起源的“肿瘤”与真正的肿瘤。科恩海姆所做的观察仍然是当代知识体系的一部分，例如否定炎症细胞的无细胞起源。科恩海姆的工作为当前关于过敏、肉芽肿形成以及与结核病相关的病理变化的观念提供了基础。同样，我们关于炎症的病理生化观点最终基于对微循环和毛细血管通透性变化的认识。
