Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Neuroimmunomodulation. 2024;31(1):173-182. doi: 10.1159/000540460. Epub 2024 Aug 8.
Chemokine ligands and their corresponding receptors are essential for regulating inflammatory responses. Chemokine receptors can stimulate immune activation or inhibit/promote signaling pathways by binding to specific chemokine ligands. Among these receptors, CC chemokine receptor 1 (CCR1) is extensively studied as a G protein-linked receptor target, predominantly expressed in various leukocytes, and is considered a promising target for anti-inflammatory therapy. Furthermore, CCR1 is essential for monocyte extravasation and transportation in inflammatory conditions. Its involvement in inflammatory diseases of the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease, and stroke, has been extensively studied along with its ligands. Animal models have demonstrated the beneficial effects resulting from inhibiting CCR1 or its ligands.
This review demonstrates the significance of CCR1 in CNS inflammatory diseases, the molecules implicated in the inflammatory pathway, and potential drugs or molecules for treating CNS diseases. This evidence may offer new targets or strategies for treating inflammatory CNS diseases.
趋化因子配体及其相应的受体对于调节炎症反应至关重要。趋化因子受体可以通过与特定的趋化因子配体结合来刺激免疫激活或抑制/促进信号通路。在这些受体中，CC 趋化因子受体 1（CCR1）作为 G 蛋白偶联受体的靶标得到了广泛研究，主要表达于各种白细胞中，被认为是抗炎治疗的有前途的靶点。此外，CCR1 对于炎症条件下单核细胞的渗出和运输至关重要。其与配体一起在包括多发性硬化症、阿尔茨海默病和中风在内的中枢神经系统（CNS）炎症性疾病中的作用已得到广泛研究。动物模型已经证明了抑制 CCR1 或其配体的有益效果。
本综述表明 CCR1 在中枢神经系统炎症性疾病中的重要性，以及涉及炎症途径的分子，以及用于治疗中枢神经系统疾病的潜在药物或分子。这些证据可能为治疗炎症性中枢神经系统疾病提供新的靶点或策略。
